Results 61 to 70 of about 32,218 (289)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Predicting respiratory motion for real-time tumour tracking in radiotherapy

, 2015
Purpose. Radiation therapy is a local treatment aimed at cells in and around a tumor. The goal of this study is to develop an algorithmic solution for predicting the position of a target in 3D in real time, aiming for the short fixed calibration time for
Jarusevicius, Laimonas, Krilavicius, Tomas, Simonavicius, Henrikas, Zliobaite, Indre   +3 more
core   +1 more source

Markerless liver online adaptive stereotactic radiotherapy: feasibility analysis

Physics in Medicine & Biology
Abstract Objective. Radio-opaque markers are recommended for image-guided radiotherapy in liver stereotactic ablative radiotherapy (SABR), but their implantation is invasive. We evaluate in this in-silico study the feasibility of cone-beam computed tomography-guided stereotactic online-adaptive radiotherapy (CBCT-STAR)
Julien Pierrard, Stéphanie Deheneffe, David Dechambre, Edmond Sterpin, Xavier Geets, Geneviève Van Ooteghem   +5 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Long-term patient experience with online MR-guided radiotherapy: adaptive versus non-adaptive workflow

Frontiers in Oncology
Purpose/objectiveMagnetic resonance–linear accelerator (MR-Linac) systems enable high-precision radiotherapy through real-time MR guidance and daily online adaptive treatment planning.
Fabian Weykamp, Fabian Weykamp, Fabian Weykamp, Fabian Weykamp, Charlotte Herder-Wagner, Sebastian Regnery, Sebastian Regnery, Sebastian Regnery, Jakob Liermann, Jakob Liermann, Jakob Liermann, Eva Meixner, Eva Meixner, Eva Meixner, Philipp Hoegen-Saßmannshausen, Philipp Hoegen-Saßmannshausen, Philipp Hoegen-Saßmannshausen, Philipp Hoegen-Saßmannshausen, Laila König, Laila König, Laila König, Kristin Lang, Kristin Lang, Kristin Lang, C. Katharina Renkamp, C. Katharina Renkamp, C. Katharina Renkamp, Carolin Rippke, Carolin Rippke, Carolin Rippke, Sebastian Klüter, Sebastian Klüter, Sebastian Klüter, Jürgen Debus, Jürgen Debus, Jürgen Debus, Jürgen Debus, Jürgen Debus, Jürgen Debus, Juliane Hörner-Rieber, Juliane Hörner-Rieber, Juliane Hörner-Rieber, Juliane Hörner-Rieber, Juliane Hörner-Rieber   +43 more
doaj   +1 more source

Automatic 3D Monte-Carlo-based secondary dose calculation for online verification of 1.5 T magnetic resonance imaging guided radiotherapy

Physics and Imaging in Radiation Oncology, 2021
Background and purpose: Hybrid magnetic resonance linear accelerator (MR-Linac) systems represent a novel technology for online adaptive radiotherapy.
Marcel Nachbar, David Mönnich, Oliver Dohm, Melissa Friedlein, Daniel Zips, Daniela Thorwarth   +5 more
doaj   +1 more source

The effect of modulated electro-hyperthermia on local disease control in HIV-positive and -negative cervical cancer women in South Africa : early results from a phase III randomised controlled trial [PDF]

, 2019
Background : The global burden of cervical cancer remains high with the highest morbidity and mortality rates reported in developing countries. Hyperthermia as a chemo- and radiosensitiser has shown to improve treatment outcomes.
Ayeni, Olusegun Akinwale, Baeyens, Ans, Kotzen, Jeffrey Allan, Minnaar, Carrie Anne, Naidoo, Thanushree, Sharma, Vinay, Tunmer, Mariza, Vangu, Mboyo-Di-Tamba   +7 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

MR-Guided Radiotherapy for Liver Malignancies

Frontiers in Oncology, 2021
MR guided radiotherapy represents one of the most promising recent technological innovations in the field. The possibility to better visualize therapy volumes, coupled with the innovative online adaptive radiotherapy and motion management approaches ...
Luca Boldrini, Stefanie Corradini, Cihan Gani, Lauren Henke, Ali Hosni, Angela Romano, Laura Dawson   +6 more
doaj   +1 more source

Three-Dimensional Dose Prediction for Lung IMRT Patients with Deep Neural Networks: Robust Learning from Heterogeneous Beam Configurations

, 2019
The use of neural networks to directly predict three-dimensional dose distributions for automatic planning is becoming popular. However, the existing methods only use patient anatomy as input and assume consistent beam configuration for all patients in ...
Barragan Montero, Ana Maria, Geets, Xavier, Jiang, Steve, Lin, Mu-Han, Lu, Weiguo, Nguyen, Dan, Norouzi-Kandalan, Roya, Sterpin, Edmond   +7 more
core   +1 more source