Results 141 to 150 of about 593,092 (290)

Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis

Cancer Science, EarlyView.
Using bioinformatic analysis, LCSC models, and transgenic mice, we demonstrate that co‐inhibition of Wnt3a and Loxl2 potently triggers ferroptosis and inhibits orthotopic liver tumorigenesis. The enhanced antitumor effect upon dual targeting, mediated through ZEB1 upregulation, highlights a promising combinatory approach against HCC.
Guanghui Ren, Qingwei Cong, Jing Wang, Wenyue Gao, Yunpeng Guan, Lianxin Zhu, Ying Zhu   +6 more
wiley   +1 more source

Prediction of the therapeutic mechanism of Sugemule-4 in insomnia treatment using network pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Su R, Wang J, Su D, Su R, Sa C, Bao L.
europepmc   +1 more source

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

Bacteria-metabolite butyrate boosts anti-PD1 efficacy in colorectal cancer patient-derived organoids through activating autologous tumour-infiltrating <i>GNLY</i> ⁺CD8⁺ T cells. [PDF]

Gut
Zhang Y, Song W, Zhou L, Wei S, Xu L, Li X, Yu J.   +6 more
europepmc   +1 more source

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

MiR-122-5p modulates ferroptosis via SLC7A11: A potential therapeutic target in autoimmune hepatitis. [PDF]

J Transl Autoimmun
Suo Y, Wang Y, Su Y, Wang Q, Jia J, Zhao X.   +5 more
europepmc   +1 more source

New Approach to Supporting Stakeholders in English Medium Instruction through a Global Online Community

International Journal of Applied Linguistics, EarlyView.
ABSTRACT With the internationalisation of higher education, English medium instruction (EMI) has become increasingly common in non‐English‐speaking contexts. However, research highlights a range of challenges in EMI implementation, including insufficient collaboration between content and language teachers, limited professional development opportunities
Jingwen Zhou, Nadia Lamprecht
wiley   +1 more source

OTMODE: an optimal transport theory-based framework for identifying differential features in single-cell multi-omics data. [PDF]

Bioinformatics
Su H, Zhang C, Wang FQ, She CH, Chen X, Dang X, Lei Y, Ni K, Xiong Z, Yin D, Yang X, Feng H, Li PH, Yang W.   +13 more
europepmc   +1 more source

Designing for Sustainability: Emerging Professional Roles and Capabilities for Designers in the 21st Century

International Journal of Art &Design Education, EarlyView.
Abstract Design Practice is shifting towards transdisciplinary, collaborative and problem‐based approaches in response to complex challenges of a changing world including societal issues and the climate crisis. However, the nature of emerging roles for designers aiming to contribute to sustainability transitions, and the capabilities that empower ...
Charlotte Kessler, Janice Rieger
wiley   +1 more source

Unraveling the therapeutic mechanism of Xiezhuo Yishen Decoction in uric acid nephropathy: Active compounds, key targets, and pathway regulation via network pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Wang C, Liu W, Zhao Q, Gao X.
europepmc   +1 more source