Results 161 to 170 of about 597,773 (286)

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

open access: yesCell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu   +7 more
wiley   +1 more source

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

open access: yesThe FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou   +6 more
wiley   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl   +10 more
wiley   +1 more source

Designing for Sustainability: Emerging Professional Roles and Capabilities for Designers in the 21st Century

open access: yesInternational Journal of Art &Design Education, EarlyView.
Abstract Design Practice is shifting towards transdisciplinary, collaborative and problem‐based approaches in response to complex challenges of a changing world including societal issues and the climate crisis. However, the nature of emerging roles for designers aiming to contribute to sustainability transitions, and the capabilities that empower ...
Charlotte Kessler, Janice Rieger
wiley   +1 more source

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