Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model
Integrative Zoology, EarlyView.UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang +5 more
wiley +1 more source
Network toxicology-driven insights on nitrogen-based flame retardant-induced hepatotoxicity: Computational prediction and experimental validation. [PDF]
Medicine (Baltimore)Qu Y, Li G, Wang H, Peng Y.
europepmc +1 more source
Integrative Zoology, EarlyView.Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu +3 more
wiley +1 more source
Transcriptomics Unveil Dsx1 as a Critical Regulator in Sexual Dimorphism of Crustaceans
Integrative Zoology, EarlyView.Sexually dimorphic traits are involved in reproductive competition and are shaped by sex‐biased gene expression. This study identifies Dsx1 as a key male‐biased gene in Morinoia aosen and demonstrates through RNA interference that its disruption feminizes male‐specific T3 leg structures.
Yan Tong +8 more
wiley +1 more source
Selective divergence between Grokipedia and Wikipedia articles. [PDF]
Proc Natl Acad Sci U S AMohammadi S, Yasseri T.
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Pseudonyms, Propaganda, and Prints: The Life and Political Caricatures of William Dent, 1782–931
Journal for Eighteenth-Century Studies, EarlyView.Abstract ‘Dent was probably an amateur and nothing is known of his life’, state Bryant and Heneage. Despite contributing to caricature's ‘golden age’, William Dent remains overlooked compared to contemporaries like James Gillray. Dent's extensive portfolio (1782–93) and rumoured role as a Pittite propagandist have not secured his place in the canon of ...
Callum D. Smith
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Mechanism prediction of Wenjing Tongluo Powder for post-laparoscopic shoulder pain: A network pharmacology study. [PDF]
Medicine (Baltimore)Wei Z, Yu H, Yu S, Wang Y.
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Andrology, EarlyView.Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos +4 more
wiley +1 more source
Analysis of the molecular mechanism underlying di(2-ethylhexyl) phthalate-induced bladder carcinogenesis via network toxicology and molecular docking approaches: An observational study. [PDF]
Medicine (Baltimore)Jiang M +5 more
europepmc +1 more source