Results 61 to 70 of about 597,773 (286)

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

open access: yesAdvanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji   +10 more
wiley   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao   +11 more
wiley   +1 more source

BugCast: A podcast about insects [PDF]

open access: yes, 2006
Podcast--you may have heard the word, but you don\u27t know what it means. I can assure you that if you have kids in high school or college, they will know.
Rice, Marlin E.
core   +2 more sources

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

open access: yesAdvanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan   +19 more
wiley   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo   +13 more
wiley   +1 more source

Book Review of the Encyclopedia of Female Pioneers in Online Learning

open access: yesOpen Praxis, 2022
Bainbridge, Susan & Wark, Norine. (2022). The Encyclopedia of Female Pioneers in Online Learning. Routledge. 492 pages. ISBN 9781003275329 (eBook). https://doi.org/10.4324/9781003275329.
Sajid Hussain
doaj  

Fiction et forme encyclopédique : Wookieepedia, Dragon Ball Wiki et Cie.

open access: yesStrenae, 2011
Wookieepedia, Final Fantasy Wiki, Dragon Ball Wiki, Memory Alpha, WoWWiki... So many online encyclopedias deal with famous young adult and children’s fiction, through an often vast number of articles, tackling all sorts of subjects (stories, technologies,
Benoît Berthou
doaj   +1 more source

The coronavirus disease COVID-19’s coverage in Ukrainian and European encyclopedias

open access: yesЕнциклопедичний Вісник України, 2020
Today, humans have the phase of the social organization evolution, in which information, communication technologies, and knowledge are fundamental objects of production, as well as the digital environment is an important space for the development of ...
Mykola Zhelezniak, Oleksandr Ishchenko
doaj   +1 more source

Encyclopedic knowledge in the mobile age [PDF]

open access: yes, 2008
The aim of this chapter is to shed some light on the changing nature of all-encompassing collections of represented knowledge, how knowledge may be socially constructed and shared, and whether perspectives may be shifting due to greater mobility and ...
Kukulska-Hulme, Agnes
core  

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang   +8 more
wiley   +1 more source

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