Results 41 to 50 of about 19,286 (280)

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Methods for Structuring Knowledge in Online Encyclopedias

Современные информационные технологии и IT-образование
Currently, several online encyclopedias are being developed in Russian. The Great Russian Encyclopedia (GRE), the Russian-language encyclopedia Ruwiki are being created.
Irina Kobozeva, Natalia Loukachevitch, Maria Panich, Fedor Sadkovsky, Eugeny Raevsky   +4 more
doaj   +1 more source

Secondary Sources: Top Ten [PDF]

, 2005
Secondary sources are a legal researcher\u27s best friend. They are a great place to begin researching a new topic as they provide a framework for understanding the subject.
Zago, Susan Drisko
core   +1 more source

Identification of Design Principles [PDF]

, 2004
This report identifies those design principles for a (possibly new) query and transformation language for the Web supporting inference that are considered essential. Based upon these design principles an initial strawman is selected.
Badea, Liviu, Berger, Sacha, Bry, François, Furche, Tim, Koch, Christoph, Schaffert, Sebastian   +5 more
core   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Using Encyclopedic Texts for Training and Inference of Artificial Neural Networks

Современные информационные технологии и IT-образование
The article explores the use of texts from online encyclopedias, such as Wikipedia and RUWIKI, for training and query processing by artificial neural networks (ANNs) of large language models (LLMs).
Vladimir Medeyko
doaj   +1 more source

Challenges in geotagging encyclopaedias

Studia Lexicographica, 2021
Encyclopaedias, as a reliable source of knowledge produced by experts and lexicographers, are, among other characteristics, known for their reliability, accuracy, and precision.
Jasmina Tolj, Ivan Smolčić, Petra Bago
doaj   +1 more source

First Snag, One LibGuide Done!, and Why Cataloging Helps Patrons [PDF]

, 2012
Working on my transgender LibGuide started off smoothly, but I ran into a problem when I went back later and tried to follow the links to the online reference collection. None of the links worked!
Leone, Hannah R.
core   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source