Results 41 to 50 of about 19,421 (294)

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Methods for Structuring Knowledge in Online Encyclopedias

Современные информационные технологии и IT-образование
Currently, several online encyclopedias are being developed in Russian. The Great Russian Encyclopedia (GRE), the Russian-language encyclopedia Ruwiki are being created.
Irina Kobozeva, Natalia Loukachevitch, Maria Panich, Fedor Sadkovsky, Eugeny Raevsky   +4 more
doaj   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Using Encyclopedic Texts for Training and Inference of Artificial Neural Networks

Современные информационные технологии и IT-образование
The article explores the use of texts from online encyclopedias, such as Wikipedia and RUWIKI, for training and query processing by artificial neural networks (ANNs) of large language models (LLMs).
Vladimir Medeyko
doaj   +1 more source

Challenges in geotagging encyclopaedias

Studia Lexicographica, 2021
Encyclopaedias, as a reliable source of knowledge produced by experts and lexicographers, are, among other characteristics, known for their reliability, accuracy, and precision.
Jasmina Tolj, Ivan Smolčić, Petra Bago
doaj   +1 more source

The canonization of German-language digital literature [PDF]

, 2009
In his paper, "The Canonization of German-language Digital Literature," Florian Hartling discusses "Net Literature," a relatively young phenomenon, that has its roots in experimental visual and concrete poetry and hypertext.
Hartling, Florian
core  

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Media education technologies in developing students' professional competence [PDF]

, 2018
While pervasive healthcare systems bear the potential to provide patients with a new quality of medical homecare, the complexity of such systems raises fundamental questions of behavior, communication and technology acceptance.
Biletskyi, V. S., Onkovych, H., Yanyshyn, O.   +2 more
core   +3 more sources

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

On the digital republishing of Ukrainian literary classics [PDF]

Енциклопедичний Вісник України
This communication examines the creation and implementation of a series of interconnected online encyclopedias dedicated to the works of prominent Ukrainian figures: Taras Shevchenko, Ivan Franko, Mykhailo Hrushevsky, and Lesia ...
Vladyslav Mukha
doaj   +1 more source