Results 251 to 260 of about 15,174,398 (300)

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao   +8 more
wiley   +1 more source

Predicting the Reactivity of Acyclic Silylenes and Germylenes in Hydrogen Activation Using Machine Learning

open access: yesAdvanced Science, EarlyView.
Statistical models for the prediction of the energy profile of H2 activation by silylenes and germylenes were developed. A simple model based on increments of the elements in α‐position enabled robust energy prediction, extrapolation to new structures, and transferability to new tetrylenes and substrates.
Michelle Kleinhaus   +4 more
wiley   +1 more source

Improving Paediatric Surgical Teaching and Learning in a Medical Program Through Online Learning. [PDF]

open access: yesJ Paediatr Child Health
Bowen SI   +5 more
europepmc   +1 more source

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

open access: yesAdvanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan   +5 more
wiley   +1 more source
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A Theory of Online Learning as Online Participation

Computers and Education, 2009
In this paper, an initial theory of online learning as online participation is suggested. It is argued that online learner participation (1) is a complex process of taking part and maintaining relations with others, (2) is supported by physical and psychological tools, (3) is not synonymous with talking or writing, and (4) is supported by all kinds of ...
Stefan Hrastinski
exaly   +2 more sources

Interactive online learning

Pattern Recognition and Image Analysis, 2007
This paper describes a system for visual object recognition based on mobile augmented reality gear. The user can train the system to the recognition of objects online using advanced methods of interaction with mobile systems: Hand gestures and speech input control “virtual menus,” which are displayed as overlays within the camera image.
Heidemann, Gunther   +3 more
openaire   +2 more sources

Online Learning

Proceedings of the 2017 ACM SIGMIS Conference on Computers and People Research, 2017
The use of Technology to facilitate better learning and training is gaining momentum worldwide, reducing the temporal and spatial problems associated with traditional learning. Despite its several benefits, retaining students in online platforms is challenging.
openaire   +2 more sources

Online Learning and Online Convex Optimization

Foundations and Trends® in Machine Learning, 2012
Online learning is a well established learning paradigm which has both theoretical and practical appeals. The goal of online learning is to make a sequence of accurate predictions given knowledge of the correct answer to previous prediction tasks and possibly additional available information.
openaire   +2 more sources

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