Results 151 to 160 of about 8,908,516 (251)

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Digital Health Information Use, Trust, and Language-Related Disparities in Health Literacy in South Tyrol, Italy: Cross-Sectional Survey Study. [PDF]

JMIR Form Res
Ausserhofer D, Barbieri V, Lombardo S, Gärtner T, Eisendle K, Piccoliori G, Engl A, Wiedermann CJ.   +7 more
europepmc   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

Online-Mediation

, 2001
Unter Online-Mediation sind internet gestützte Verfahren zu verstehen, welche die Kommunikation zwischen Konfliktparteien konstruktiv gestalten. Erste Anwendungen sind in jüngster Zeit vor allem bei Streitfällen im E-Commerce und in umstrittenen ...
Märker, Oliver, Trénel, Matthias, Gordon, Thomas F.   +2 more
core  

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Children worldwide gain benefits, face risks online

, 2016
A majority of children say they learn something new online at least every week, but large numbers still face risks online, according to the Global Kids Online Research Synthesis Report 2015 – 2016 produced by the UNICEF Office of Research – Innocenti and
Global Kids Online
core  

From restrictions to awareness: Examining the varied relationship between mediation strategies and parental awareness of adolescents online sexual experiences across age groups

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
This study examines the relationship of parental concerns and attitudes toward restriction strategies with the implementation of parental mediation strategies and parental awareness of their children’s involvement in sexting.
Luka Stanić
doaj  

Perceived digital health information support and self-rated health among Chinese adults: physical activity mediation and chronic health condition moderation. [PDF]

Front Public Health
Yang X, Fu X, Wu Z, Xiao L, Luo M.
europepmc   +1 more source

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Some Consideration on the Mediation Contract [PDF]

Interaction between people is the most different and diverse, from harmony to the conflict , so that when conflicts arise between them, because they are bound by a contract, the legal system offers a wide range of possibilities for settlement, the ...
Stoica, Veronica
core