Results 41 to 50 of about 72,129 (258)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

The Antecedents of Online Purchase Intention During Covid-19: A Serial Mediation Approach

Qubahan Academic Journal
The objective of this study is to investigate how consumers’ online shopping experience influence online purchase intention through a serial mediation model using stimulus organism response (SOR) framework. 378 valid responses were collected from online
S. Dheepalakshmi, R. Geetha
doaj   +1 more source

A Transactional Framework of Parenting for Children’s Internet Use: A Narrative Review of Parental Self-Efficacy, Mediation, and Awareness of Online Risks

International Journal of Communication, 2023
Parental concern about children’s media use has been a recurring issue in research on parent-child communication. For the past three decades, online risks associated with children’s Internet use have also become a particular concern.
Seffetullah Kuldas, Aikaterini Sargioti, James O'Higgins Norman, Elisabeth Staksrud   +3 more
doaj  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Behind the Curtains of e-State: Determinants of Online Sexual Harassment among Estonian Children [PDF]

Studies of Transition States and Societies, 2012
This article analyses the risk of receiving online sexual messages and experiencing harm among Estonian children. In particular, the paper examines the association between receiving sexual messages and behavioural, psychological and demographic ...
Veronika Kalmus, Mare Ainsaar, Kadri Soo
doaj  

Gli archivi online per gli utenti: premesse per un modello di gestione della qualità

JLIS.it, 2017
The traditional paradigm of archival mediation had to come to grips with the web environment. If guides, inventories and indexes act as mediation tools between what is inside archives and whoever needs to access them, traditional archival finding aids ...
Pierluigi Feliciati, Alessandro Alfier
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Exploring the relationships between physical accessibility, online behavior, and travel behaviour for grocery shopping in Scarborough, Canada

Journal of Urban Mobility
The influence of proximity on travel behavior differs when online behavior is considered. While many studies treat online behavior as a moderator that weakens the benefits of local accessibility for sustainable travel, this moderation approach assumes ...
Chunjiang Li, Christopher D. Higgins, Ignacio Tiznado-Aitken, Steven Farber   +3 more
doaj   +1 more source