Results 81 to 90 of about 1,153,411 (253)

Online Recommender System

open access: yesInternational Journal for Research in Applied Science and Engineering Technology, 2021
As the size of the e-commerce market grows, the consequences of it are appearing throughout society.The business Environment of a company changes from a product center to a user center and introduces a recommendation system. However, the existing research has shown a limitation in deriving customized recommendation information to reflect the
openaire   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

open access: yesFEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Evaluating the Acceptance of Massive Open Online Courses (MOOCs) among Students of Shiraz University of Medical Sciences

open access: yesپیاورد سلامت, 2019
Background and Aim: MOOC stands for Massive Open Online Course and is an instructional approach that allows hundreds of thousands of students to access -- typically free of charge -- online courses anywhere around the world.
Mohammad Hossein Ronaghi
doaj  

qtlXplorer: an online systems genetics browser in the Eucalyptus Genome Integrative Explorer (EucGenIE). [PDF]

open access: yesBMC Bioinformatics, 2021
Christie N   +9 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Assessing the Role of Applying E-Learning in the Training and Learning Process from Faculty Members΄ Point of View at Payam Noor University, Mazandaran [PDF]

open access: yesInterdisciplinary Journal of Virtual Learning in Medical Sciences, 2012
Introduction: The present study reviews the role of employing E-learning in the teaching and learning process at Payam Noor University, Mazandaran province, Iran, from the faculty members' point of view during 2012.Material & Methods: This study is ...
Mojtaba Rezai Rad   +1 more
doaj  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Investigating the Factors Affecting the Motivation of Nurses for Sharing Knowledge Online

open access: yesIranian Journal of Nursing and Midwifery Research
Background: Considering the importance of Knowledge Sharing (KS) among nurses, this research aimed to investigate the factors influencing the motivation of nurses for sharing knowledge online.
Mina Yousefi   +3 more
doaj   +1 more source

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