Results 121 to 130 of about 4,617,678 (304)

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Reasons for delayed admission after stroke: results of a qualitative and quantitative survey

Patient Preference and Adherence, 2019
Anna Christina Alegiani,1 Sindy Albrecht,1 Anne Christin Rahn,2,3 Sascha Köpke,2 Götz Thomalla,1 Christoph Heesen41Department of Neurology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; 2Institute of Social Medicine & ...
Alegiani AC, Albrecht S, Rahn AC, Köpke S, Thomalla G, Heesen C   +5 more
doaj  

User-Behavior Based Detection of Infection Onset [PDF]

, 2010
A major vector of computer infection is through exploiting software or design flaws in networked applications such as the browser. Malicious code can be fetched and executed on a victim’s machine without the user’s permission, as in drive-by download ...
Crowell, Alexander, Ma, Qiang, Xu, Kui, Yao, Danfeng(Daphne)   +3 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Early-onset anorexia nervosa: a scoping review and management guidelines

Journal of Eating Disorders
Background Anorexia nervosa (AN) is a serious multifactorial eating disorder characterized by insufficient nutritional intake to maintain a minimum normal weight for one's age and height, a fear of gaining weight and a distorted body image.
Anaël Ayrolles, Julia Clarke, Nathalie Godart, Céline André-Carletti, Clémentine Barbe, Anne Bargiacchi, Corinne Blanchet, Florence Bergametti, Valérie Bertrand, Emmanuelle Caldagues, Marylene Caquard, Danielle Castellotti, Richard Delorme, Laurence Dreno, Dominique Feneon Landou, Priscille Gerardin, Selim Guessoum, Ludovic Gicquel, Juliane Léger, Stéphanie Legras, Lucile Noel, Anne Fjellestad-Paulsen, Hélène Poncet-Kalifa, Flora Bat-Pitault, Coline Stordeur   +24 more
doaj   +1 more source

Dynamics of Onset and Progression in Amyotrophic Lateral Sclerosis

Brain Sciences
This review focuses on the complexities of amyotrophic lateral sclerosis (ALS) onset, highlighting the insidious nature of the disease and the challenges in defining its precise origin and early pathogenic mechanisms.
Michael Swash, Mamede de Carvalho
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

lncRNA TPRG1-AS1 Screened the Onset of Acute Coronary Syndromes and Predicted Severity and the Occurrence of MACE During Patients’ Hospitalization

Journal of Inflammation Research, 2023
Fan Zhang,* Wei Li,* Yingying Zhang, Dong Wang, Jing Li, Chengpeng Li, Liqun He Department of Cardiology, Intervention Cardiology Center, Wuhan No.1 Hospital, Wuhan, 430022, People’s Republic of China*These authors contributed equally to this
Zhang F, Li W, Zhang Y, Wang D, Li J, Li C, He L   +6 more
doaj  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Bacterial membrane vesicles in the pathogenesis and treatment of inflammatory bowel disease

Gut Microbes
Inflammatory bowel disease (IBD) is a chronic and debilitating condition of relapsing and remitting inflammation in the gastrointestinal tract. Conventional therapeutic approaches for IBD have shown limited efficacy and detrimental side effects, leading ...
Chinasa Valerie Olovo, Dickson Kofi Wiredu Ocansey, Ying Ji, Xinxiang Huang, Min Xu   +4 more
doaj   +1 more source