Results 101 to 110 of about 4,617,678 (304)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Long-term course of borderline dysplasia: a 26-year follow-up of nonoperative hips in patients undergoing unilateral acetabular rotational osteotomy

Bone & Joint Open
Aims: We conducted a minimum 20-year follow-up of nonoperated hips that presented with borderline dysplasia (BD), defined as a lateral centre-edge angle (LCEA) of 18° to 25°, in cases of bilateral developmental dysplasia of the hip (DDH) where ...
Ayano Amagami, Hajime Sugiyama, Mitsuru Saito   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Characterizing rainfall patterns and dynamics in the Little Ruaha catchment, southern Tanzania

Frontiers in Water
Water resources in many regions are increasingly under pressure due to population growth, agricultural expansion, and climate variability, which presents significant challenges in maintaining sustainable water supplies.
Florence H. Mahay, Patrick C. Valimba, Madaka H. Tumbo, Fides J. Izdori, Mohamed F. Mwabumba, Winfred B. Mbungu   +5 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Onset of Rotational Damping in Superdeformed Nuclei

, 1996
We discuss damping of the collective rotational motion in $A\sim 150$ superdeformed nuclei by means of a shell model combining the cranked Nilsson mean-filed and the surface-delta two-body residual force.
Anderson, Arview, Bengtsson, Bengtsson, Bengtsston, Bohr, Bush, Cohen, Dagnall, Døssing, Ericson, Faessler, Fallon, Green, Herskind, Herskind, Herskind, Herskind, K. Yoshida, Lauritzen, Leoni, M. Matsuo, Matsuo, Mottelson, Mottelson, Myers, Nilsson, Ring, Schiffer, Schiffer, Twin, Twin, Werner, Åberg, Åberg, Åberg   +35 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Onset of Convection in an Inclined Anisotropic Porous Layer with Internal Heat Generation

Fluids, 2019
The onset of convection in an inclined porous layer which is heated internally by a uniform distribution of heat sources is considered. We investigate the combined effects of inclination, anisotropy and internal heat generation on the linear instability ...
Leiv Storesletten, D. Andrew S. Rees
doaj   +1 more source

Onset of incommensurability in quantum spin chains

, 2002
In quantum spin chains, it has been observed that the incommensurability occurs near valence-bond-solid (VBS)-type solvable points, and the correlation length becomes shortest at VBS-type points.
Affleck I., Bursill R., Bursill R. J., Fáth G., Kolezhuk A., Kolezhuk A., Majumdar C. K., Nomura K., Schollwöck U., Tonegawa T.   +9 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source