Results 81 to 90 of about 4,617,678 (304)

Solitary magnetic perturbations at the ELM onset [PDF]

, 2012
Edge localised modes (ELMs) allow maintaining sufficient purity of tokamak H-mode plasmas and thus enable stationary H-mode. On the other hand in a future device ELMs may cause divertor power flux densities far in excess of tolerable material limits. The
A. Burckhart, Becoulet M., Bobkov V., Boom J., Braams B.J., Burckhart A., C. Fuchs, E. Viezzer, F. Sommer, Federici G., Fischer R., Fundamenski W., H. Zohm, H.K. Park, H.W. Müller, Huysmans G., Hölzl M., J.E. Boom, Kass T., Kirk A., Koslowski H., Loarte A., Luhmann N.C., M. Garcia-Munoz, M. Hölzl, M. Maraschek, M.G. Dunne, Neuhauser J., Nunes I., P.A. Schneider, Perez C., R. Dux, R. Fischer, R.P. Wenninger, Ryter F., Schirmer J., Schmid A., Schmid A., Snyder P., Sommer F., T. Eich, T. Lunt, V. Igochine, Valovic M., W. Suttrop, Zohm H.   +45 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong.

, 2003
BACKGROUND: Health authorities worldwide, especially in the Asia Pacific region, are seeking effective public-health interventions in the continuing epidemic of severe acute respiratory syndrome (SARS).
Abu-Raddad, Laith J, Anderson, Roy M, Chan, King-Pan, Chau, Patsy, Donnelly, Christl A, Ferguson, Neil M, Fraser, Christophe, Ghani, Azra C, Hedley, Anthony J, Ho, Lai-Ming, Kong, James HB, Lam, Tai-Hing, Lau, Edith MC, Leung, Gabriel M, Liu, Shao-Haei, Riley, Steven, Thach, Thuan-Quoc, Tsang, Thomas, Tse, Lai-Yin   +18 more
core   +1 more source

Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy. [PDF]

, 2016
Myotonic dystrophy type I (DM1) exhibits distinctive disease specific phenotypes and the accelerated onset of a spectrum of age-associated pathologies.
Abdallah, Walid F, Choi, Jongkyu, Comai, Lucio, Dansithong, Warunee, Dixon, Donald M, Jordan, Maria C, Lee, Han Shin, Reddy, Sita, Roos, Kenneth P, Trac, Brandon   +9 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Characteristics of Alzheimer’s Disease and Mild Cognitive Impairment Influenced by the Time of Onset

Dementia and Geriatric Cognitive Disorders Extra
Introduction: Although the prevalence of Alzheimer’s disease (AD) is higher in older people compared to younger people, dementia has also been documented in younger adults.
Hiroyuki Sato, Miho Ota, Ayako Kitabatake, Yuriko Numata, Takumi Takahashi, Masashi Tamura, Kiyotaka Nemoto, Tetsuaki Arai   +7 more
doaj   +1 more source

Robust changes in tropical rainy season length at 1.5 °C and 2 °C

Environmental Research Letters, 2018
Changes in the hydrological cycle are among the aspects of climate change most relevant for human systems and ecosystems. Besides trends in overall wetting or drying, changes in temporal characteristics of wetting and drying are of crucial importance in ...
Fahad Saeed, Ingo Bethke, Erich Fischer, Stephanie Legutke, Hideo Shiogama, Dáithí A Stone, Carl-Friedrich Schleussner   +6 more
doaj   +1 more source

Phase reconstruction of spectrograms based on a model of repeated audio events

, 2015
Phase recovery of modified spectrograms is a major issue in audio signal processing applications, such as source separation. This paper introduces a novel technique for estimating the phases of components in complex mixtures within onset frames in the ...
Badeau, Roland, David, Bertrand, Magron, Paul   +2 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A Basic Tutorial on Novelty and Activation Functions for Music Signal Processing

Transactions of the International Society for Music Information Retrieval
In Music Information Retrieval (MIR), a general goal is to recognize times of novelty within music recordings. This includes estimating structural boundaries through the detection of changes in harmony, tempo, or instrumentation and identifying onsets of
Meinard Müller, Ching-Yu Chiu
doaj   +1 more source