Results 91 to 100 of about 4,496,566 (351)

Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study [PDF]

, 2019
Background: Recent reports have described the efficacy of rituximab in treating steroid-dependent nephrotic syndrome (SDNS) in pediatric patients. However, few reports describe data regarding adult-onset SDNS.
Masuda, Tomohiro, Ito, Yasuhiko, Kato, Sawako, Kitamura, Hiroshi, Kato, Noritoshi, Tsuzuki, Toyonori, Katsuno, Takayuki, Tsuboi, Naotake, Maruyama, Shoichi, Saito, Shoji, Kosugi, Tomoki, Ishimoto, Takuji   +11 more
core   +1 more source

Predictors of Success in Horizontal Strabismus Surgery: Insights from a Prospective Study

Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Introduction: Strabismus is an eye disorder characterized by misalignment of the eyes, which can occur in individuals of any age. This study explored the surgical outcomes of horizontal strabismus correction in patients, aiming to provide insights into ...
Aurellia Valmai Tjujitno, Reni Prastyani, Joni Susanto, Rozalina Loebis, Luki Indriaswati, Lely Retno Wulandari   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Practical application of real-time sub-seasonal monsoon onset forecasting and monitoring for decision-making

Frontiers in Climate
Skilful monsoon onset forecasts are highly sought after in West Africa, due to the importance of monsoon onset for supporting agriculture, disease prevalence and energy provision.
Elisabeth M. Thompson, Elisabeth M. Thompson, Elisabeth M. Thompson, Caroline M. Wainwright, Caroline M. Wainwright, Caroline M. Wainwright, Linda C. Hirons, Linda C. Hirons, Steven J. Woolnough, Steven J. Woolnough   +9 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Characteristics of Alzheimer’s Disease and Mild Cognitive Impairment Influenced by the Time of Onset

Dementia and Geriatric Cognitive Disorders Extra
Introduction: Although the prevalence of Alzheimer’s disease (AD) is higher in older people compared to younger people, dementia has also been documented in younger adults.
Hiroyuki Sato, Miho Ota, Ayako Kitabatake, Yuriko Numata, Takumi Takahashi, Masashi Tamura, Kiyotaka Nemoto, Tetsuaki Arai   +7 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A Basic Tutorial on Novelty and Activation Functions for Music Signal Processing

Transactions of the International Society for Music Information Retrieval
In Music Information Retrieval (MIR), a general goal is to recognize times of novelty within music recordings. This includes estimating structural boundaries through the detection of changes in harmony, tempo, or instrumentation and identifying onsets of
Meinard Müller, Ching-Yu Chiu
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source