Results 91 to 100 of about 2,815,843 (315)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Characterizing rainfall patterns and dynamics in the Little Ruaha catchment, southern Tanzania

open access: yesFrontiers in Water
Water resources in many regions are increasingly under pressure due to population growth, agricultural expansion, and climate variability, which presents significant challenges in maintaining sustainable water supplies.
Florence H. Mahay   +5 more
doaj   +1 more source

THE GENETIC BASIS OF PRIMARY ADULT-ONSET DYSTONIA

open access: yes, 2011
Objectives. To identify novel genetic loci associated with primary adult-onset dystonia (AOD) and assess candidate genes from the literature. Secondary aimes.
Esposito, Marcello
core  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Syllable Segmentation with Vowel Detection on Verse Quranic Recitation

open access: yesJOIV: International Journal on Informatics Visualization
In speech recognition, segmentation involves partitioning a continuous audio signal containing speech into smaller units or segments, such as words, phonemes, or syllables.
Timor Setiyaningsih   +2 more
doaj   +1 more source

The effect of arousals during sleep onset on estimates of sleep onset latency

open access: yes, 2000
It is well established that insomniacs overestimate sleep-onset latency. Furthermore, there is evidence that brief arousals from sleep may occur more frequently in insomnia.
Smith, S   +3 more
core   +1 more source

A superposed epoch analysis of auroral evolution during substorm growth, onset and recovery: open magnetic flux control of substorm intensity [PDF]

open access: yes, 2009
We perform two superposed epoch analyses of the auroral evolution during substorms using the FUV instrument on the Imager for Magnetopause-to-Aurora Global Explorer ( IMAGE) spacecraft. The larger of the two studies includes nearly 2000 substorms.
Hubert, Benoît   +27 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Onset of Convection in an Inclined Anisotropic Porous Layer with Internal Heat Generation

open access: yesFluids, 2019
The onset of convection in an inclined porous layer which is heated internally by a uniform distribution of heat sources is considered. We investigate the combined effects of inclination, anisotropy and internal heat generation on the linear instability ...
Leiv Storesletten, D. Andrew S. Rees
doaj   +1 more source

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