Results 111 to 120 of about 2,815,843 (315)
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Revisiting Childhood-Onset Systemic Lupus Erythematosus
Childhood-onset systemic lupus erythematosus (cSLE) is a chronic autoimmune disease with a multisystemic involvement diagnosed during childhood. The disease is marked by the production of autoantibodies targeting self-antigens, often before symptoms ...
Pınar Özge Avar-Aydın +1 more
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Reasons for delayed admission after stroke: results of a qualitative and quantitative survey
Patient Preference and Adherence, 2019 Anna Christina Alegiani,1 Sindy Albrecht,1 Anne Christin Rahn,2,3 Sascha Köpke,2 Götz Thomalla,1 Christoph Heesen41Department of Neurology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; 2Institute of Social Medicine & ...
Alegiani AC +5 more
doaj
Brain and BehaviorBackground Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the degeneration of both lower and upper motor neurons (UMN).
Dongchao Shen +5 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji +13 more
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Dynamics of Onset and Progression in Amyotrophic Lateral Sclerosis
Brain SciencesThis review focuses on the complexities of amyotrophic lateral sclerosis (ALS) onset, highlighting the insidious nature of the disease and the challenges in defining its precise origin and early pathogenic mechanisms.
Michael Swash, Mamede de Carvalho
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Evaluation of the onset time and intubation conditions of rocuronium bromide in children
, 1997 Publisher's copy made available with the permission of the publisher © 1997 Australian Society of AnaesthetistsWe have assessed, in children aged three to eight years, the intubating conditions after administration of rocuronium 0.6 mg/kg at 50 or 60 ...
McDonald, P., Laing, R., Sainsbury, D.
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