Results 71 to 80 of about 2,815,843 (315)

Characteristics of Alzheimer’s Disease and Mild Cognitive Impairment Influenced by the Time of Onset

open access: yesDementia and Geriatric Cognitive Disorders Extra
Introduction: Although the prevalence of Alzheimer’s disease (AD) is higher in older people compared to younger people, dementia has also been documented in younger adults.
Hiroyuki Sato   +7 more
doaj   +1 more source

Robust changes in tropical rainy season length at 1.5 °C and 2 °C

open access: yesEnvironmental Research Letters, 2018
Changes in the hydrological cycle are among the aspects of climate change most relevant for human systems and ecosystems. Besides trends in overall wetting or drying, changes in temporal characteristics of wetting and drying are of crucial importance in ...
Fahad Saeed   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

A Basic Tutorial on Novelty and Activation Functions for Music Signal Processing

open access: yesTransactions of the International Society for Music Information Retrieval
In Music Information Retrieval (MIR), a general goal is to recognize times of novelty within music recordings. This includes estimating structural boundaries through the detection of changes in harmony, tempo, or instrumentation and identifying onsets of
Meinard Müller, Ching-Yu Chiu
doaj   +1 more source

Humanitarian Indicator Toolkit - Rapid Onset [PDF]

open access: yes, 2013
Oxfam's humanitarian effectiveness reviews critically examine the performance of selected humanitarian responses against 12 recognised quality benchmarks.
Walden, Vivien
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Characteristics of late-onset spondyloarthritis in Japan: A retrospective cohort study

open access: yes, 2019
Spondyloarthritis may be increasingly present in older patients as life expectancy increases. We investigated clinical differences between early-onset and late-onset spondyloarthritis in Japan.
Koga, Tomohiro   +7 more
core   +1 more source

Early and Late Onset Seizures After Cerebrovascular Disease [PDF]

open access: yes, 2015
Objectives:This study aimed to compare seizure types, clinical and demographic features, treatment response and prognosis among patients with early and late onset post-stroke seizures.Methods:A retrospective evaluation was made of the data of 46 patients
Sevda Yıldız GÖKÇEER   +9 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Late-onset Blount's disease

open access: yes, 2011
Includes bibliographical references.In 1937 WP Blount published a review of tibia vara or osteochondrosis deformans of the proximal tibia. Late-onset Blount's disease is varus deformity of the proximal tibia that occurs at or after 6 years old (excluding
White, Clive David
core  

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