Results 61 to 70 of about 4,617,678 (304)
Late onset of Huntington's disease [PDF]
, 1985 Twenty-five patients with late-onset Huntington's disease were studied; motor impairment appeared at age 50 years or later. The average age at onset of chorea was 57.5 years, with an average age at diagnosis of 63.1 years.
Myers, R. H. +7 more
core
Jump at the onset of saltation
, 2011 We reveal a discontinuous transition in the saturated flux for aeolian saltation by simulating explicitly particle motion in turbulent flow. The discontinuity is followed by a coexistence interval with two metastable solutions.
G. H. Keulegan +11 more
core +1 more source
Rest tremor in Parkinson's disease: body distribution and time of appearance [PDF]
, 2017 Objective To assess body distribution and timing of appearance of rest tremor in Parkinson's disease. Methods Information was obtained by a computerized database containing historical information collected at the first visit and data collected during the
Custodero, Giacomo Emanuele +8 more
core +1 more source
Postgraduate Medical Journal, 2004 Abstract Young onset dementia is a challenging clinical problem with potentially devastating medical and social consequences. The differential diagnosis is wide, and includes a number of rare sporadic and hereditary diseases. However, accurate diagnosis is often possible, and all patients should be thoroughly investigated to identify ...
E L, Sampson, J D, Warren, M N, Rossor
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Primary Psychosis: Risk and Protective Factors and Early Detection of the Onset
Diagnostics, 2021 Primary psychosis, which includes schizophrenia and other psychoses not caused by other psychic or physical conditions, has a strong impact worldwide in terms of disability, suffering and costs.
Claudio Brasso +6 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Laryngeal sensitivity in patients with amyotrophic lateral sclerosis [PDF]
, 2016 Recent studies have shown the involvement of the sensory nervous system in patients with amyotrophic lateral sclerosis (ALS). The aim of our study was to investigate the correlation between the laryngeal sensitivity deficit and the type of ALS onset ...
BIASIOTTA, ANTONELLA +13 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
The Onset of Deconfinement in Nuclear Collisions [PDF]
, 1999 We first consider the origin of colour deconfinement, comparing in particular spontaneous symmetry breaking and percolation. Next we specify the onset of deconfinement in nuclear collisions through parton percolation, and with parameters determined at ...
Abreu +26 more
core +2 more sources