Results 61 to 70 of about 2,815,843 (315)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Predictors of Success in Horizontal Strabismus Surgery: Insights from a Prospective Study

Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Introduction: Strabismus is an eye disorder characterized by misalignment of the eyes, which can occur in individuals of any age. This study explored the surgical outcomes of horizontal strabismus correction in patients, aiming to provide insights into ...
Aurellia Valmai Tjujitno, Reni Prastyani, Joni Susanto, Rozalina Loebis, Luki Indriaswati, Lely Retno Wulandari   +5 more
doaj   +1 more source

Service and support requirements of people with younger onset dementia and their families final report, August, 2012 [PDF]

, 2012
In 2011, Alzheimer’s Australia NSW (AlzNSW) was engaged by Ageing, Disability and Home Care (ADHC) to research the service and support requirements of people with younger onset dementia and their families in New South Wales.
Kylie Sait, Jo-Ann Brown
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Practical application of real-time sub-seasonal monsoon onset forecasting and monitoring for decision-making

Frontiers in Climate
Skilful monsoon onset forecasts are highly sought after in West Africa, due to the importance of monsoon onset for supporting agriculture, disease prevalence and energy provision.
Elisabeth M. Thompson, Elisabeth M. Thompson, Elisabeth M. Thompson, Caroline M. Wainwright, Caroline M. Wainwright, Caroline M. Wainwright, Linda C. Hirons, Linda C. Hirons, Steven J. Woolnough, Steven J. Woolnough   +9 more
doaj   +1 more source

onset-offset of activity - Figure S2ab

, 2019
Dataset used to analyse the onset and offset of daily activity. Results are shown in supplementary figure 1 (panels a and b)
Kapyla, Teemu, Marcel Visser (3322110), Ulgezen, Zeynep, Meerlo, Peter, Davide Dominoni (6787352), Visser, Marcel, Dominoni, Davide, Peter Meerlo (6787349), Spoelstra, Kamiel, Kamiel Spoelstra (163398), Zeynep Ulgezen (6787340), Teemu Kapyla (6787346)   +11 more
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Humanitarian Indicator Toolkit - Slow Onset [PDF]

, 2013
The humanitarian effectiveness reviews critically examine the performance of selected humanitarian responses against 12 recognised quality benchmarks. Following the protocol of the Humanitarian Indicator Tool (HIT), external humanitarian experts review ...
Walden, Vivien
core  

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source