Results 91 to 100 of about 169,797 (297)
Engineering Students' Thinking About Technical Systems: An Ontological Categories Approach
Frontiers in Education, 2020 This paper aims at identifying ontological categories as higher-order knowledge structures that underlie engineering students' thinking about technical systems.
Sarah Isabelle Hofer +3 more
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Ontological imagination: transcending methodological solipsism and the promise of interdisciplinary studies [PDF]
, 2013 This text is a presentation of the notion of ontological imagination. It constitutes an attempt to merge two traditions: critical sociology and science and technology studies - STS (together with the Actor-Network Theory – ANT).
Nowak, Andrzej W., Andrzej W. Nowak
core +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
On the Impossibility of Successful Ontological Arguments [PDF]
, 2002 This paper presents a novel objection to ontological arguments. This objection aims at showing that ontological arguments in general, given the intrinsic nature of their conclusion, are of an impossible nature.
Franceschi, Paul
core
UNVEILING THE QURANIC WORLDVIEW: GOD AND HUMAN RELATIONSHIP
Studia Theologica VarsaviensiaThis article explores the foundational structure of the Quranic worldview, with a particular focus on the relationship between God and humans. It presents this relationship as a dynamic and complex dichotomy, where God is the ultimate and singular ...
Safia Al-Shameri
doaj +1 more source
Social Studies of Science, 2014 Ontology, and in particular, the so-called ontological turn, is the topic of a recent themed issue of Social Studies of Science (Volume 43, Issue 3, 2013). Ontology, or metaphysics, is in philosophy concerned with what there is, how it is, and forms of being.
openaire +4 more sources
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source