Results 71 to 80 of about 111,452 (313)
Bioinformatics, 2004 Abstract Summary: Although dozens of biological ontologies have been created and deployed, relatively little attention has been given to using ontologies to represent behavior. Ontologies for two different behavior systems are described here.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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Do ontological deficiencies in modeling grammars matter?
, 2011 Conceptual modeling grammars are a fundamental means for specifying information systems requirements. However, the actual usage of these grammars is only poorly understood.
Recker, Jan +4 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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Hugh MacColl's Ontological Domains
, 2009 The most influential approach to the logic of non-existents is certainly the one stemming from the Frege-Russell tradition. One of the most important early dissidents was indeed Hugh MacColl.
Rahman, Shahid, Shahid Rahman
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, 2015 En recientes décadas se ha observado un renovado interés por algunos de los temas clásicos de la ontología, desde áreas de conocimiento externas a la filosofía, sin embargo, este renacimiento ontológico ha «estimulado» una multiplicidad y diversidad de teorías y concepciones «ontológicas» que ha dado como consecuencia una proliferación de «ontologías ...
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Ontological imagination: transcending methodological solipsism and the promise of interdisciplinary studies [PDF]
, 2013 This text is a presentation of the notion of ontological imagination. It constitutes an attempt to merge two traditions: critical sociology and science and technology studies - STS (together with the Actor-Network Theory – ANT).
Nowak, Andrzej W., Andrzej W. Nowak
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
An ontological analysis of some biological ontologies [PDF]
Frontiers in Genetics, 2012 The functional importance of biological entities makes their understanding, analysis, and representation essential in modern biology. Arguably, semantic representation necessary for machine interoperability is a far more difficult task than syntactic representation, necessitating conceptual schema and ontologies for in-silico biological knowledge ...
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