Results 81 to 90 of about 111,452 (313)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Open Hypermedia as a Navigational Interface to Ontological Information Spaces

, 2001
Ontologies provide a powerful tool for distributed agent-based information systems. However, in their raw form they can be difficult for users to interact with directly.
Mark J. Weal, Luc Moreau, Hughes, Gareth V., Moreau, Luc, Weal, Mark J., Gareth V. Hughes, Millard, David E., David E. Millard   +7 more
core   +1 more source

Ontology Knowledge Mining for Ontology Alignment [PDF]

International Journal of Computational Intelligence Systems, 2016
Comme l'alignement des ontologies facilite l'échange de connaissances entre les sources de données hétérogènes, plusieurs méthodes ont été introduites dans la littérature. Cependant, peu d'entre elles se sont intéressées à la diminution de la complexité du problème et à la réduction de l'espace de recherche des correspondances entre les ontologies d ...
Idoudi, Rihab, Saheb Ettabaa, Karim, Solaiman, Basel, Hamrouni, Kamel   +3 more
openaire   +4 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The Measurement of Perceived Ontological Deficiencies of Conceptual Modeling Grammars [PDF]

, 2010
Over recent years, many scholars have studied the conceptual modeling of information systems based on a theory of ontological expressiveness. This theory offers four constructs that inform properties of modeling grammars in the form of ontological ...
Recker, Jan C., Michael Rosemann, Jan Recker, Rosemann, Michael   +3 more
core   +1 more source

Merdeka Belajar Kampus Merdeka (MBKM) in Islamic higher education institutions: Ontological, epistemological and axiological reviews

INSANIA: Jurnal Pemikiran Alternatif Kependidikan
This study examines the Merdeka Belajar Kampus Merdeka (MBKM) program in Islamic Higher Education Institutions (PTKI) from ontological, epistemological, and axiological perspectives. The research aims to understand the unique characteristics of MBKM and
Mawi Khusni Albar, Sangkot Sirait, Sibawaihi   +2 more
doaj   +1 more source

Psychological effects and epistemological education through mathematics "abstraction" and "construction" [PDF]

Social Sciences and Education Research Review, 2015
This study is part of a broader research which will be found in future work, Psychology and epistemology of mathematical creation, complementary work of experimental research psychology mathematics, whose investigative approach, promoting the combination
Aurel Pera
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The KnowWhereGraph ontology

Journal of Web Semantics
KnowWhereGraph is one of the largest fully publicly available geospatial knowledge graphs. It includes data from 30 layers on natural hazards (e.g., hurricanes, wildfires), climate variables (e.g., air temperature, precipitation), soil properties, crop and land-cover types, demographics, and human health, various place and region identifiers, among ...
Cogan Shimizu, Shirly Stephen, Adrita Barua, Ling Cai 0002, Antrea Christou, Kitty Currier, Abhilekha Dalal, Colby K. Fisher, Pascal Hitzler, Krzysztof Janowicz, Wenwen Li 0002, Zilong Liu 0003, Mohammad Saeid Mahdavinejad, Gengchen Mai, Dean Rehberger, Mark Schildhauer, Meilin Shi, Sanaz Saki Norouzi, Yuanyuan Tian 0002, Sizhe Wang, Zhangyu Wang, Joseph Zalewski, Lu Zhou 0005, Rui Zhu 0008   +23 more
openaire   +4 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source