Results 61 to 70 of about 169,797 (297)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Sharing healthcare data by manipulating ontological individuals
, 2011 The purpose of this chapter is twofold: 1.We primarily want to disseminate our experiences of using the power of ontological engineering when dealing with interoperability and the problem of data sharing in heterogeneous computational environments in ...
Juric, R., Kataria, P.
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
International Journal of Human-Computer Studies, 1997 We analyse the construction as well as the role of ontologies in knowledge sharing and reuse for complex industrial applications. In this article, the practical use of ontologies in large-scale applications not restricted to knowledge-based systems is demonstrated, for the domain of engineering systems modelling, simulation and design.
Borst, P., Akkermans, H., Top, J.L.
openaire +4 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Exploring languaging through an ontological register [PDF]
, 2022 Law and Mol (2020) provide an insightful critique to dominant approaches to language, arguing that “to talk of language is to imply that it is possible to disentangle how people talk (or sign or write) from the practices in which they do so.
Demuro, Eugenia, Gurney, Laura
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Philosophical Transactions of the Royal Society B: Biological Sciences, 2008 There is room for considerable cooperation between archaeology and neuroscience, but in order for this to happen we need to think about the interactions among brain–body–world, in which each of these three terms acts as cause and effect, without attributing a causally determinant position to any one.
openaire +3 more sources
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
On the Predominance of Ontological Recognition in Tillich's Theology : Grace in Recognition [PDF]
, 2005 Paul Tillich’s theology is sometimes called philosophical theology or ontological theology because it is based on the ontological relationship between God and human beings.
キクチ, ジュン, 菊地, 順, 3555
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