Results 181 to 190 of about 3,980 (280)

Unity, Polarity, Symmetry, Manifestation: An Ontology of Differentiation and Re-Potentialization

This essay develops an ontology of differentiation and re-potentialization based on P.R. Sarkar’s Four-Chamber Model. It begins from the problem of how stable forms, identities, meanings, and structures emerge at all. While materialist approaches tend to reduce such phenomena to physical processes, non-materialist ontologies often respond by ...
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Transformation and Excellence in an RN-to-BSN Program: A Ten-Year Journey. [PDF]

Nurs Adm Q
MacIntyre R, Beck MD.
europepmc   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Liminal Bioethics for Liminal Statuses: A New Method for Analysing Novel Biological Entities. [PDF]

Bioethics
Wee M, Singh I.
europepmc   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Unity as the Foundational Trait of Reality and Awareness (MetaEthics)

This paper argues that Unity, understood as structural coherence, is the most fundamental trait of the non-optional field constituted by Reality and Awareness.
Rodrigues Bento, Francisco Manuel
core  

Relearning the epistemology, history, and future of neuropsychiatry. [PDF]

Front Hum Neurosci
Castro Martínez JC, Botero-Rodríguez F, Ramírez-Bermúdez J, Bell V, Oviedo-Lugo G, Santacruz-Escudero JM, Iragorri Á, Camprodon J, Lawlor B, Santamaría-García H.   +9 more
europepmc   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Personal Happiness Vs. Communal/European Welfare – Ontological Incongruence, Parallelism, or Congruence?

The article explores. philosophically (ontologically), a central question of our time: why doesn’t material prosperity guarantee authentic happiness? The proposed answer suggests that true happiness is not only normative but also ontological.
Stefaroi, Petru
core  

A structured analysis of the concept of brain death. [PDF]

Theor Med Bioeth
Beckmann RJ.
europepmc   +1 more source