Results 41 to 50 of about 398,735 (283)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Consideration of Application for Subvention by the Organization of African Trade Union Unity (OATUU) [PDF]

, 1978
Council of Ministers Thirtieth Ordinary Session- February 1978This report considers the application for subvention from the Organization of African Unity by the Organization of African Trade Union Unity (OATUU) for the financial year 1978/1979 ...
Organization of African Unity
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Financial rules and regulations of the Organization of African Unity

, 1965
The financial rules and regulations of the Organization of African Unity promulgated by the Council of Ministers govern the financial administration of all the organs of the ...
Organization of African Unity
core   +2 more sources

From Platonic anamnesis to the architectonics of philosophical knowledge: The historical-philosophical status of reminiscence [PDF]

Известия Саратовского университета. Новая серия: Серия Философия. Психология. Педагогика
Introduction. The article explores the phenomenon of reminiscence as a possible method of constructing the history of philosophy, which transforms the Platonic concept of recollection (anamnesis) into a tool for synthesizing universal ideas and ...
Romaschenko, Maria A., Romashchenko, Alexander Alexandrovich   +1 more
doaj   +1 more source

GREGORY PALAMAS ’ ONTOLOGY AS THEORETICAL FOUNDATION OF AXIOLOGICAL ASPECTS OF THE PHILOSOPHY OF „ALL-UNITY“ [PDF]

Konštantínove listy/Constantine's Letters, 2016
The influence of hesychastic traditions on the Russian culture can be found in cultural practices since the 15th century. In the 19th century, the tradition of hesychasm determined semantic coordinates of ontological aspects of the philosophy of "All-Unity". This strategy is aimed at creation of unity which would have ontological basis.
Kletskova, I., Lyahchylin, A.
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Influence of Ibn Arabi's Ontological Foundations on Formation of the Embodiment of Acts [PDF]

حکمت صدرایی, 2020
"The embodiment of deeds", or the ontological relationship of human actions and beliefs with pleasures and pains of afterlife, is one of the most important and complex issues raised in resurrection.
مهدی صفایی اصل, صدرالدین طاهری موسوی   +1 more
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Plural Subject Approach to Social Ontology and the Sharing Values Issue

Phenomenology and Mind, 2016
I address the issue of the unity of social ontology despite the extreme variety of social entities: groups, money, promises, governments, laws, etc. Then, I focus on Gilbert’s account of social ontology as an ontology specifically dealing with groups as ...
Francesca De Vecchi
doaj   +1 more source