Results 51 to 60 of about 3,980 (280)
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
The Influence of Ibn Arabi's Ontological Foundations on Formation of the Embodiment of Acts [PDF]
حکمت صدرایی, 2020 "The embodiment of deeds", or the ontological relationship of human actions and beliefs with pleasures and pains of afterlife, is one of the most important and complex issues raised in resurrection.
مهدی صفایی اصل +1 more
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The Plural Subject Approach to Social Ontology and the Sharing Values Issue
Phenomenology and Mind, 2016 I address the issue of the unity of social ontology despite the extreme variety of social entities: groups, money, promises, governments, laws, etc. Then, I focus on Gilbert’s account of social ontology as an ontology specifically dealing with groups as ...
Francesca De Vecchi
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Philosophy, Theory, and Practice in BiologyThe cell’s ability to metabolize foodstuffs, synthesize proteins and nucleic acids, and transduce extracellular signals, all rely on an intricate intracellular network of biological systems.
Ross Stein
doaj +2 more sources
Ontological Analysis of the Knowledge in Transcendent Philosophy and Its Relation to the Correspondence Theory [PDF]
حکمت معاصر:Mulla Sadra’s philosophy and his Transcendent Wisdom (Hikmat al-Muta‘aliyah) are deeply interwoven with the doctrines of the primacy of existence (asalat al-wujud), the unity of existence (wahdat al-wujud), and the gradation of existence (tashkik al ...
ali fathi
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source