Results 41 to 50 of about 113,360 (251)
Matching disease and phenotype ontologies in the ontology alignment evaluation initiative
Journal of Biomedical Semantics, 2017 Background The disease and phenotype track was designed to evaluate the relative performance of ontology matching systems that generate mappings between source ontologies.
Ian Harrow +9 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Forgetting Fragments from Evolving Ontologies [PDF]
, 2010 Ontologies underpin the semantic web; they define the concepts and their relationships contained in a data source. An increasing number of ontologies are available on-line, but an ontology that combines information from many different sources can grow ...
Packer, Heather S. +2 more
core +2 more sources
How orthogonal are the OBO Foundry ontologies?
Journal of Biomedical Semantics, 2011 Background Ontologies in biomedicine facilitate information integration, data exchange, search and query of biomedical data, and other critical knowledge-intensive tasks.
Ghazvinian Amir +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
SMARTPHONE-BASED APPROACH TO ADVANCED DRIVER ASSISTANCE SYSTEM (ADAS) RESEARCH AND DEVELOPMENT [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2015 Subject of Research.The paper deals with findings and presents asmartphone-based approach to advanced driver assistance system (ADAS) research and development.The approach is based on the data of smartphone cameras and sensors.
I. B. Lashkov +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Metrics and methods for comparative ontology evaluation
Ciência da Informação, 2017 While progress has been made toward describing the need for ontology evaluation and offering proposals concerning what properties to measure and how, work remains to develop ontology evaluation as a rigorous discipline.
Amanda Hicks
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Enriching Ontologies with Multilingual Information [PDF]
, 2009 Multilinguality in ontologies has become an impending need for institutions worldwide that have to deal with data and linguistic resources in different natural languages.
Montiel Ponsoda, Elena +3 more
core