Results 51 to 60 of about 113,360 (251)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

On the succinctness of query rewriting over shallow ontologies [PDF]

, 2014
We investigate the succinctness problem for conjunctive query rewritings over OWL2QL ontologies of depth 1 and 2 by means of hypergraph programs computing Boolean functions. Both positive and negative results are obtained.
Podolskii, Vladimir, Kikot, Stanislav, Roman Kontchakov, Vladimir V. Podolskii, Podolskii, V., Michael Zakharyaschev, Zakharyaschev, Michael, Stanislav Kikot, Kontchakov, Roman   +8 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Evolution of Inconsistent Ontologies in Physics [PDF]

, 2011
Inconsistency robustness in autonomous software can be seen as a problem of automated reasoning about ontology evolution. Formal ontologies specify the knowledge that software systems use when reasoning about the entities in their domain.
Bundy, Alan, Chan, Michael, Lehmann, Jos
core  

Software architecture for managing the Fisheries ontologies lifecycle [PDF]

, 2007
This document describes the software architecture for implementing a system for managing the fisheries ontologies lifecycle, cornerstone of WP7. The lifecycle described in this deliverable is an instantiation of the possible lifecycles that can be ...
Soonho, Kim, Caracciolo, Caterina, Haase, Peter, Bagdanov, Andrew, Asuncion, Gomez-Perez, Iglesias Sucasas, Marta, Munoz-Garcia, Oscar, Wang, Yimin, Suarez-Figueroa, Maria-del-Carmen   +8 more
core   +1 more source

OnEX: Exploring changes in life science ontologies

BMC Bioinformatics, 2009
Background Numerous ontologies have recently been developed in life sciences to support a consistent annotation of biological objects, such as genes or proteins.
Gross Anika, Kirsten Toralf, Hartung Michael, Rahm Erhard   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Conceptual modelling and the quality of ontologies: A comparison between object-role modelling and the object paradigm [PDF]

, 2010
Ontologies are key enablers for sharing precise and machine-understandable semantics among different applications and parties. Yet, for ontologies to meet these expectations, their quality must be of a good standard.
Lycett, M, de Cesare, S, Al-Asswad, MM, Al-Debei, MM   +3 more
core   +3 more sources

A Survey on Ontologies’ Adaptability and Interoperability

Cybernetics and Information Technologies
Interoperability issues emerge due to differences in the sizes and expressive powers of ontologies. Although ontologies are expressive, they tend to lack flexibility. Research shows that specialized ontologies are not merely advantageous for a particular
Dahir Sarah, Qadi Abderrahim El
doaj   +1 more source