Results 51 to 60 of about 275,690 (365)

Accurate Identification of Ontology Alignments at Different Granularity Levels

IEEE Access, 2017
As more and more ontologies are defined with different terms, ontology matching plays a crucial role in addressing the semantic heterogeneity problem in many different disciplines.
Xiaocao Hu, Zhiyong Feng, Shizhan Chen, Keman Huang, Jianqiang Li, Mengchu Zhou   +5 more
doaj   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

How orthogonal are the OBO Foundry ontologies?

Journal of Biomedical Semantics, 2011
Background Ontologies in biomedicine facilitate information integration, data exchange, search and query of biomedical data, and other critical knowledge-intensive tasks.
Ghazvinian Amir, Noy Natalya F, Musen Mark A   +2 more
doaj   +1 more source

Developing and using ontologies in behavioural science: addressing issues raised [version 2; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2023
Ontologies are ways of representing aspects of the world in terms of uniquely defined classes of ‘entities’ and relationships between them. They are widely used in biological science, data science and commerce because they provide clarity, consistency ...
Nelli Hankonen, Robert West, Janna Hastings, Susan Michie, Marie Johnston, Alison J. Wright   +5 more
doaj  

A Review of Multilingualism in and for Ontologies [PDF]

arXiv, 2022
The Multilingual Semantic Web has been in focus for over a decade. Multilingualism in Linked Data and RDF has shown substantial adoption, but this is unclear for ontologies since the last review 15 years ago. One of the design goals for OWL was internationalisation, with the aim that an ontology is usable across languages and cultures. Much research to
arxiv  

Content-based ontology ranking [PDF]

, 2006
Techniques to rank ontologies are crucial to aid and encourage the re-use of publicly available ontologies. This paper presents a system that obtains a list of ontologies from a search engine that contain the terms provided by a knowledge engineer and ...
Alani, Harith, Jones, Matthew
core   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

An ontological analysis of some biological ontologies [PDF]

Frontiers in Genetics, 2012
The functional importance of biological entities makes their understanding, analysis, and representation essential in modern biology. Arguably, semantic representation necessary for machine interoperability is a far more difficult task than syntactic representation, necessitating conceptual schema and ontologies for in-silico biological knowledge ...
openaire   +4 more sources