Results 111 to 120 of about 1,189,057 (413)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

The Information Flow Foundation for Conceptual Knowledge Organization [PDF]

Dynamism and Stability in Knowledge Organization, volume 7 of Advances in Knowledge Organization, pages 111-117. Ergon Verlag, 2000. Proceedings of the Sixth International ISKO Conference, 2018
The sharing of ontologies between diverse communities of discourse allows them to compare their own information structures with that of other communities that share a common terminology and semantics - ontology sharing facilitates interoperability between online knowledge organizations.
arxiv  

Aber-OWL: a framework for ontology-based data access in biology [PDF]

, 2014
Many ontologies have been developed in biology and these ontologies increasingly contain large volumes of formalized knowledge commonly expressed in the Web Ontology Language (OWL). Computational access to the knowledge contained within these ontologies relies on the use of automated reasoning.
arxiv   +1 more source

A layered framework for pattern-based ontology evolution [PDF]

, 2011
The challenge of ontology-driven modelling of information components is well known in both academia and industry. In this paper, we present a novel approach to deal with customisation and abstraction of ontology-based model evolution.
Abgaz, Yalemisew, Javed, Muhammad, Pahl, Claus   +2 more
core   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Participatory design of a continuous care ontology : towards a user-driven ontology engineering methodology [PDF]

, 2011
The patient room of the future would be able to sense the needs and preferences of the patients and nurses and adapt itself accordingly by combining all the heterogeneous data offered by the different technologies. This goal can be achieved by developing
Ackaert, Ann, Bleumes, Lizzy, De Turck, Filip, De Zutter, Saar, Jacobs, An, Ongenae, Femke, Sulmon, Nicky, Van Gils, Mieke, Verhoeve, Piet, Verstraete, Mathijs   +9 more
core  

A core ontology for business process analysis [PDF]

, 2008
Business Process Management (BPM) aims at supporting the whole life-cycle necessary to deploy and maintain business processes in organisations. An important step of the BPM life-cycle is the analysis of the processes deployed in companies.
Alves de Medeiros, Ana Karla, Domingue, John, Pedrinaci, Carlos   +2 more
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Ontobull and BFOConvert: Web-based programs to support automatic ontology conversion [PDF]

, 2016
When a widely reused ontology appears in a new version which is not compatible with older versions, the ontologies reusing it need to be updated accordingly.
Jie, Zheng, Smith, Barry, Xiang, Ong Edison:, Yongqun, He   +3 more
core  

Decoherence and Ontology [PDF]

, 2019
This paper discusses the consequences of quantum mechanics for our understanding of physical reality, particularly regarding how classical concepts emerge from quantum laws; how common sense logic stands out as a special case of quantum logic applied to macroscopic objects; how causality and locality are found to be “provincial” consequences of quanta;
openaire   +4 more sources