Results 151 to 160 of about 491,544 (310)
Research and Practice in Technology Enhanced Learning, 2021 Danièle Allard, Riichiro Mizoguchi
doaj +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
Ontology learning for semantic web services
, 2009 Semantic Web Services promise automatic service discovery and composition, relying heavily on domain ontology as a core component. With large Web Service repository, manual ontology development is proving a bottleneck (with associated expense and likely ...
Lycett, M +5 more
core
Advanced Science, EarlyView.CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He +17 more
wiley +1 more source
Towards Ontology Mapping: DL View or Graph View?
, 2006 Ontology is important in sharing and reusing knowledge. It also plays a crucial role in the development of Semantic Web. The paper discusses the DL(Description Logic) and graph view on ontology. Different perspectives have different models and approaches
Huang, Yongjian, Shadbolt, Nigel
core
ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells
Advanced Science, EarlyView.With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao +16 more
wiley +1 more source
Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source
An Editorial Workflow Approach For Collaborative Ontology Development
, 2009 The widespread use of ontologies in the last years has raised new challenges for their development and maintenance. Ontology development has transformed from a process normally performed by one ontology engineer into a process performed collaboratively ...
Corcho, Oscar +4 more
core
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Intelligent automated essay scoring under uncertainty using type 2 neutrosophic ontologies. [PDF]
Sci RepDarwish SM, Bagi NA, El-Shoafy NA.
europepmc +1 more source