Results 141 to 150 of about 601,327 (249)

Toward a Smart Learning Health System: An Ontology-Based Framework. [PDF]

Learn Health Syst
Ma M, Yu P, Hickman LD.
europepmc   +1 more source

Ontology mapping: the state of the art

, 2003
Ontology mapping is seen as a solution provider in today's landscape of ontology research. As the number of ontologies that are made publicly available and accessible on the Web increases steadily, so does the need for applications to use them.
Kalfoglou, Yannis, Schorlemmer, Marco
core  

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

R-GCRED: a retrieval-grounded and calibrated risk estimation for depression prediction and screening recommendation framework. [PDF]

Front Artif Intell
Saidi F, Almulla M.
europepmc   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

OntoCodex: a multi-agent biomedical ontology enrichment framework. [PDF]

Npj Health Syst
Feng J, Yu Y, Dong A, Hu X, Niu S, Li P, Dang Y, Abdelhameed A, Bian J, Jiang X, Tao C.   +10 more
europepmc   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Epigenetic Insights in Pediatric Multiple Sclerosis: DNA Methylation Highlights an Involvement of Epstein-Barr Virus Infection and Host Immune Networks. [PDF]

Neurol Neuroimmunol Neuroinflamm
Corona A, Tosi M, Zollo A, Barizzone N, Pomella N, Simone M, Protti A, Berardinelli AL, Gallo A, Canavese C, Vecchio D, Cocco E, Moiola L, Conti MZ, Malucchi S, Papa A, Mingione A, Monzani C, Annovazzi P, Grimaldi LME, Lanzillo R, Rasia S, Bova SM, Ravanini P, Caushi F, Torri Clerici VLAM, Sotgiu S, Priori A, Trojano M, Amato MP, Bergamaschi R, Pilotto S, Pozzilli C, Cottone S, Santangelo G, De Luca G, Pugliatti M, Ghezzi A, D'Alfonso S, Martinelli Boneschi F, PEDIGREE study group.   +40 more
europepmc   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Ontology

The Reasoner, 2007
Robert Arp
doaj