Results 51 to 60 of about 1,266,792 (389)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Interpreting Literary Characters Through Diagnostic Properties
HumanitiesThis paper investigates an approach to studying analytic relations (identity, similarity, borrowing, etc.) between literary characters using properties and, in particular, properties that are interpretively considered as diagnostic.
Emilio M. Sanfilippo +2 more
doaj +1 more source
Ontologies Change and Queries Break: Towards a Solution [PDF]
, 2006 Keeping track of ontology changes is becoming a critical issue for ontology-based applications. Updating an ontology that is in use may result in inconsistencies between the ontology and the knowledge base, dependent ontologies and applications/services.
Alani, Harith +2 more
core
Why national health research systems matter [PDF]
, 2005 Some of the most outstanding problems in Computer Science (e.g. access to heterogeneous information sources, use of different e-commerce standards, ontology translation, etc.) are often approached through the identification of ontology mappings. A manual
World Health Organization +10 more
core +5 more sources
From Ontology to Ontologies to Trans-Ontology
Forum Philosophicum, 2016 This paper describes the implications of the transition from Ontology conceived as fundamental metaphysical logos to ontologies construed as postmodern historical applications of this, and then, finally, to Trans-Ontology as the ultimate, futuristic innovation of Transhumanism.
openaire +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Uberon: towards a comprehensive multi-species anatomy ontology [PDF]
, 2009 The lack of a single unified species-neutral ontology covering the anatomy of a variety of metazoans is a hindrance to translating model organism research to human health.
Chris Mungall +3 more
core +2 more sources
The Human Phenotype Ontology in 2017
Nucleic Acids Res., 2016 Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic abnormalities in which the individual components of the phenotype are observed and described.
Sebastian Köhler +58 more
semanticscholar +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source