Results 51 to 60 of about 373,534 (285)

Aspect OntoMaven - Aspect-Oriented Ontology Development and Configuration With OntoMaven [PDF]

arXiv, 2015
In agile ontology-based software engineering projects support for modular reuse of ontologies from large existing remote repositories, ontology project life cycle management, and transitive dependency management are important needs. The contribution of this paper is a new design artifact called OntoMaven combined with a unified approach to ontology ...
arxiv  

Aber-OWL: a framework for ontology-based data access in biology [PDF]

, 2014
Many ontologies have been developed in biology and these ontologies increasingly contain large volumes of formalized knowledge commonly expressed in the Web Ontology Language (OWL). Computational access to the knowledge contained within these ontologies relies on the use of automated reasoning.
arxiv   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

The Information Flow Foundation for Conceptual Knowledge Organization [PDF]

Dynamism and Stability in Knowledge Organization, volume 7 of Advances in Knowledge Organization, pages 111-117. Ergon Verlag, 2000. Proceedings of the Sixth International ISKO Conference, 2018
The sharing of ontologies between diverse communities of discourse allows them to compare their own information structures with that of other communities that share a common terminology and semantics - ontology sharing facilitates interoperability between online knowledge organizations.
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

FEBS Open Bio, EarlyView.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo, Yupeng Yin, Susu Guo, Xiaoyan Chen, Suyan Xie, Shiqin Chen, Yan Huang   +6 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Rethinking rules and social practices. The design of urban spaces in the post-Covid-19 lockdown

TeMA: Journal of Land Use, Mobility and Environment, 2020
In the last months a pandemic has changed the daily life of billions of people. Among the efforts to reduce the impact of the disease, social distancing has had huge consequences and raised may concerns, from the inadequacy of contemporary urban design ...
Maria Rosaria Stufano Melone, Stefano Borgo   +1 more
doaj   +1 more source

A Framework for Evaluating Agricultural Ontologies [PDF]

arXiv, 2019
An ontology is a formal representation of domain knowledge, which can be interpreted by machines. In recent years, ontologies have become a major tool for domain knowledge representation and a core component of many knowledge management systems, decision support systems and other intelligent systems, inter alia, in the context of agriculture.
arxiv  

No-signaling in topos formulation and a common ontological basis for classical and non-classical physical theories

Zagadnienia Filozoficzne w Nauce, 2020
Starting from logical structures of classical and quantum mechanics we reconstruct the logic of so-called no-signaling theories, where the correlations among subsystems of a composite system are restricted only by a simplest form of causality forbidding ...
Marek Kuś
doaj