Results 51 to 60 of about 601,327 (249)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
A Prototype for Automating Ontology Learning and Ontology Evolution [PDF]
, 2013 Ontology learning supports ontology engineers in the complex task of creating an ontology. Updating ontologies at regular intervals greatly increases the need for expensive expert contribution.
Wohlgenannt, Gerhard +2 more
core
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
The Intuitive Concept of Information: An Analysis
Studies in Logic, Grammar and Rhetoric, 2020 This paper seeks to determine the intuitive meaning of the concept of information by indicating its essential (definitional) features and relations with other concepts, such as that of knowledge. The term “information” – as with many other concepts, such
Król Zbigniew
doaj +1 more source
An Advanced Clinical Ontology [PDF]
, 2009 This article discusses a fundamental issues of medical ontology based on ontological theory. We focus on "anatomical structure of organs" and "abnormal states in the human body". On the basis of the investigation, we distinguish organ-
Riichiro Mizoguchi +5 more
core +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
The Gene Ontology: enhancements for 2011. [PDF]
, 2012 The Gene Ontology (GO) (http://www.geneontology.org) is a community bioinformatics resource that represents gene product function through the use of structured, controlled vocabularies.
Consortium, Gene Ontology
core +3 more sources
Studies in Logic, Grammar and Rhetoric, 2020 This paper proposes two formal models for understanding real-life dialogues, aimed at capturing argumentative structures performatively enacted during conversations.
Yaskorska-Shah Olena
doaj +1 more source
Vascular normalization confers an endothelial immune suppressive gene expression profile
Molecular Oncology, EarlyView.We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley +1 more source
Cross-Product Extensions of the Gene Ontology [PDF]
, 2009 The Gene Ontology is being normalized and extended to include computable logical definitions. These definitions are partitioned into mutually exclusive cross-product sets, many of which reference other OBO Foundry ontologies.
Michael Bada +7 more
core