Results 51 to 60 of about 583,139 (291)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
The Zaragoza’s Knowledge Graph: Open Data to Harness the City Knowledge
Information, 2020 Public administrations handle large amounts of data in relation to their internal processes as well as to the services that they offer. Following public-sector information reuse regulations and worldwide open data publication trends, these ...
Paola Espinoza-Arias +4 more
doaj +1 more source
On the reproducibility of science: unique identification of research resources in the biomedical literature [PDF]
PeerJ, 2013 Scientific reproducibility has been at the forefront of many news stories and there exist numerous initiatives to help address this problem. We posit that a contributor is simply a lack of specificity that is required to enable adequate research ...
Nicole A. Vasilevsky +6 more
doaj +2 more sources
International Journal of Human-Computer Studies, 1997 We analyse the construction as well as the role of ontologies in knowledge sharing and reuse for complex industrial applications. In this article, the practical use of ontologies in large-scale applications not restricted to knowledge-based systems is demonstrated, for the domain of engineering systems modelling, simulation and design.
Borst, P., Akkermans, H., Top, J.L.
openaire +4 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
A Prototype for Automating Ontology Learning and Ontology Evolution [PDF]
, 2013 Ontology learning supports ontology engineers in the complex task of creating an ontology. Updating ontologies at regular intervals greatly increases the need for expensive expert contribution.
Wohlgenannt, Gerhard +2 more
core
Philosophical Transactions of the Royal Society B: Biological Sciences, 2008 There is room for considerable cooperation between archaeology and neuroscience, but in order for this to happen we need to think about the interactions among brain–body–world, in which each of these three terms acts as cause and effect, without attributing a causally determinant position to any one.
openaire +3 more sources