Results 51 to 60 of about 491,544 (310)
On the reproducibility of science: unique identification of research resources in the biomedical literature [PDF]
PeerJ, 2013 Scientific reproducibility has been at the forefront of many news stories and there exist numerous initiatives to help address this problem. We posit that a contributor is simply a lack of specificity that is required to enable adequate research ...
Nicole A. Vasilevsky +6 more
doaj +2 more sources
, 2015 En recientes décadas se ha observado un renovado interés por algunos de los temas clásicos de la ontología, desde áreas de conocimiento externas a la filosofía, sin embargo, este renacimiento ontológico ha «estimulado» una multiplicidad y diversidad de teorías y concepciones «ontológicas» que ha dado como consecuencia una proliferación de «ontologías ...
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The Zaragoza’s Knowledge Graph: Open Data to Harness the City Knowledge
Information, 2020 Public administrations handle large amounts of data in relation to their internal processes as well as to the services that they offer. Following public-sector information reuse regulations and worldwide open data publication trends, these ...
Paola Espinoza-Arias +4 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Ontology Knowledge Mining for Ontology Alignment [PDF]
International Journal of Computational Intelligence Systems, 2016 Comme l'alignement des ontologies facilite l'échange de connaissances entre les sources de données hétérogènes, plusieurs méthodes ont été introduites dans la littérature. Cependant, peu d'entre elles se sont intéressées à la diminution de la complexité du problème et à la réduction de l'espace de recherche des correspondances entre les ontologies d ...
Idoudi, Rihab +3 more
openaire +4 more sources
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
The Intuitive Concept of Information: An Analysis
Studies in Logic, Grammar and Rhetoric, 2020 This paper seeks to determine the intuitive meaning of the concept of information by indicating its essential (definitional) features and relations with other concepts, such as that of knowledge. The term “information” – as with many other concepts, such
Król Zbigniew
doaj +1 more source