Results 91 to 100 of about 1,055,752 (313)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Decentralized but Globally Coordinated Biodiversity Data

open access: yesFrontiers in Big Data, 2020
Centralized biodiversity data aggregation is too often failing societal needs due to pervasive and systemic data quality deficiencies. We argue for a novel approach that embodies the spirit of the Web (“small pieces loosely joined”) through the ...
Beckett W. Sterner   +2 more
doaj   +1 more source

Algebraic Calculi for Weighted Ontology Alignments [PDF]

open access: yes, 2016
Alignments between ontologies usually come with numerical attributes expressing the confidence of each correspondence. Semantics supporting such confidences must generalise the semantics of alignments without confidence. There exists a semantics which satisfies this but introduces a discontinuity between weighted and non-weighted interpretations ...
Inants, Armen   +2 more
openaire   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

The Information-Flow Approach to Ontology-Based Semantic Integration

open access: yes, 2010
In this article we argue for the lack of formal foundations for ontology-based semantic alignment. We analyse and formalise the basic notions of semantic matching and alignment and we situate them in the context of ontology-based alignment in open-ended ...
Kalfoglou, Yannis, Schorlemmer, Marco
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Employing Ontology-Alignment and Locality-Sensitive Hashing to Improve Attribute Interoperability in Federated eID Systems

open access: yesComplex Systems Informatics and Modeling Quarterly, 2016
Achieving interoperability, i.e. creating identity federations between different Electronic identities (eID) systems, has gained relevance throughout the past years.
Walter Priesnitz Filho   +2 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

VOAR: A Visual and Integrated Ontology Alignment Environment [PDF]

open access: yes, 2014
International audienceOntology alignment is a key process for enabling interoperability between ontology-based systems in the Linked Open Data age. From two input ontologies, this process generates an alignment (set of correspondences) between them.
Severo, Bernardo   +2 more
core   +1 more source

Ontology Text Alignment: Aligning Textual Content to Terminological Axioms

open access: yes
Despite the impressive advancements in Large Language Models (LLMs), their ability to perform reasoning and provide explainable outcomes remains a challenge, underscoring the continued relevance of ontologies in certain areas, particularly due to the reasoning and validation capabilities of ontologies.
Chen, Jieying   +3 more
openaire   +2 more sources

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