Results 151 to 160 of about 80,509 (303)

The RNA Ontology (RNAO): An ontology for integrating RNA sequence and structure data

, 2009
Biomedical Ontologies are intended to integrate diverse biomedical data to enable intelligent data-mining and facilitate translation of basic research into useful clinical knowledge.
Eric Westhof, Chris Mungall, Jane Richardson, Karen Eilbeck, Thomas Bittner, Colin Batchelor, Craig Zirbel, Jesse Stombaugh, Neocles Leontis, Rob Knight   +9 more
core  

Ontology Alignment Overview

, 2009
At present, ontologies are considered to be an appropriate solution to the problem of heterogeneity in data, since ontological methods make it possible to reach a common understanding of concepts in a particular domain.
Javier Pereira Loureiro, Alejandro Pazos Sierra, Marcos Martínez Romero, José Manuel Vázquez Naya   +3 more
core   +1 more source

A Rare Allele of ST5 From Wild Rice Enhances Salt Tolerance in Rice

Advanced Science, EarlyView.
A novel salt‐tolerance gene ST5W, characterized by a unique 36‐bp promoter insertion, is found exclusively in a small subset of Oryza rufipogon and is absent in cultivated rice. Field trials confirm ST5W significantly enhances rice yield across diverse genetic backgrounds under saline conditions.
Meng Xing, Jingfen Huang, Qiaoling Yuan, Ziyi Yang, Yanyan Wang, Mingchao Zhao, Yamin Nie, Rui Xu, Hongge Qian, Wenxi Chen, Qiaoling Zhang, Qi Du, Leiyue Geng, Yapeng Li, Ziyi Chen, Shizhuang Wang, Like Lou, Haiyuan Peng, Chongke Zheng, Xianzhi Xie, Xiaoming Zheng, Lifang Zhang, Lianguang Shang, Jiaqiang Sun, Qian Qian, Qingwen Yang, Weihua Qiao   +26 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Results of the Ontology Alignment Evaluation Initiative 2023

97139The Ontology Alignment Evaluation Initiative (OAEI) aims at comparing ontology matching systems on precisely defined test cases. These test cases can be based on ontologies of different levels of complexity and use different evaluation modalities ...
Lambrix, Patrick, Fallatah, Omaima, Monnin, Pierre, Coulet, Adrien, Ibanescu, Liliana, Hertling, Sven, Wu, Mingfang, Li, Huanyu, Nasr, Engy, Faria, Daniel, He, Yuan, Algergawy, Alsayed, Jain, Sarika, Jimenez-Ruiz, Ernesto, Hang, Dong, Trojahn, Cassia, Karam, Naouel, Horrocks, Ian, Shvaiko, Pavel, Saveta, Tzanina, Buche, Patrice, Fundulaki, Irini, Paulheim, Heiko, Cufi, Julien, Huschka, Martin, Yaman, Beyza, Zamazal, Ondrej, Vatascinova, Jana, Abd Nikooie Pour, Mina, Zhou, Lu, Li, Ying, Castro, Leyla J., Pesquita, Catia, Chen, Jiaoyan, Sousa, Guilherme   +34 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Matching disease and phenotype ontologies in the ontology alignment evaluation initiative. [PDF]

J Biomed Semantics, 2017
Harrow I, Jiménez-Ruiz E, Splendiani A, Romacker M, Woollard P, Markel S, Alam-Faruque Y, Koch M, Malone J, Waaler A.   +9 more
europepmc   +1 more source

Demo: A Community Based Approach for Managing Ontology Alignments

The Semantic Web is rapidly becoming a defacto distributed repository for semantically represented data, thus leveraging on the added on value of the network effect.
Kalfoglou, Yannis, Correndo, Gianluca, Alani, Harith, Smart, Paul R   +3 more
core  

Global Network Alignment

, 2010
Motivation: High-throughput methods for detecting molecular interactions have lead to a plethora of biological network data with much more yet to come, stimulating the development of techniques for biological network alignment.
Oleksii Kuchaiev, Natasa Przulj
core