Results 51 to 60 of about 80,509 (303)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Towards valid and reusable reference alignments — ten basic quality checks for ontology alignments and their application to three different reference data sets

Journal of Biomedical Semantics, 2012
Identifying relationships between hitherto unrelated entities in different ontologies is the key task of ontology alignment. An alignment is either manually created by domain experts or automatically by an alignment system.
Beisswanger Elena, Hahn Udo
doaj   +1 more source

A core ontology of fishery and its use in the fishery ontology service project [PDF]

, 2004
Ontology creation and document indexing are well-known, critical bottlenecks for integrating semantic services and in general for bootstrapping the Semantic Web.
Gangemi, Aldo, Keizer, Johannes, Lehmann, Jos, Pettman, Ian, Fisseha, Frehiwot, Taconet, Marc, Liang, Anita, Sini, Margerita   +7 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Multimatcher Model to Enhance Ontology Matching Using Background Knowledge

Information, 2021
Ontology matching is a rapidly emerging topic crucial for semantic web effort, data integration, and interoperability. Semantic heterogeneity is one of the most challenging aspects of ontology matching.
Sohaib Al-Yadumi, Wei-Wei Goh, Ee-Xion Tan, Noor Zaman Jhanjhi, Patrice Boursier   +4 more
doaj   +1 more source

Mechanism Design for Ontology Alignment [PDF]

International Joint Conference on Autonomous Agents and Multiagent Systems, 2017
The aim of the ontology alignment problem is to find meaningful correspondences between two ontologies represented as collections of entities. This problem can be modelled as a novel mechanism design problem on an edge-weighted bipartite graph, where each side of the graph holds each agent's private entities, and the objective is to maximise the agents'
Piotr Krysta, Minming Li, Terry R. Payne, Nan Zhi   +3 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

An Industry-Ready Machine Learning Ontology

Applied Sciences
This article presents an industry-ready ontology for the machine learning domain, which is named “ML Ontology”. While based on lightweight modelling languages, ML ontology provides novel features including built-in queries and quality assurance, as well ...
Bernhard G. Humm
doaj   +1 more source

Processing Ontology Alignments with SPARQL [PDF]

2008 International Conference on Complex, Intelligent and Software Intensive Systems, 2008
Solving problems raised by heterogeneous ontologies can be achieved by matching the ontologies and processing the resulting alignments. This is typical of data mediation in which the data must be translated from one knowledge source to another. We propose to solve the data translation problem, i.e.
Jérôme Euzenat, Axel Polleres, François Scharffe   +2 more
openaire   +1 more source