Results 51 to 60 of about 689,318 (241)

User Validation in Ontology Alignment

, 2016
User validation is one of the challenges facing the ontology alignment community, as there are limits to the quality of automated alignment algorithms. In this paper we present a broad study on user validation of ontology alignments that encompasses three distinct but interrelated aspects: the profile of the user, the services of the alignment system ...
Zlatan Dragisic, Valentina Ivanova, Patrick Lambrix, Daniel Faria, Ernesto Jiménez-Ruiz, Catia Pesquita   +5 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Multimatcher Model to Enhance Ontology Matching Using Background Knowledge

Information, 2021
Ontology matching is a rapidly emerging topic crucial for semantic web effort, data integration, and interoperability. Semantic heterogeneity is one of the most challenging aspects of ontology matching.
Sohaib Al-Yadumi, Wei-Wei Goh, Ee-Xion Tan, Noor Zaman Jhanjhi, Patrice Boursier   +4 more
doaj   +1 more source

Data Linking with Ontology Alignment [PDF]

, 2012
It is a trend to publish RDF data on the web, so that users can share information semantically. Then, linking isolated data sets together is highly needed. I would like to reduce the comparison scale by isolating the types of resources to be compared, so that it enhances the accuracy of the linking process.
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Results from experiments in ontology learning including evaluation and recommendation [PDF]

, 2007
This document describes the Ontology Learning experiments we performed in order to recommend a set of ontology learning techniques to enhance the ontology engineering process in the fisheries domain in place at FAO. Experiments have been conceived in the
Caracciolo, Caterina, D'Aquin, Mathieu, Sabou, Marta, Voelker, Johanna, Peters, Wim   +4 more
core   +1 more source

Matching biomedical ontologies through compact differential evolution algorithm

Systems Science & Control Engineering, 2019
Although biomedical ontologies have been widely used in the life science domain, the heterogeneous problem among biomedical ontologies hampers their inter-operability.
Xingsi Xue, Junfeng Chen
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The RNA structure alignment ontology [PDF]

RNA, 2009
Multiple sequence alignments are powerful tools for understanding the structures, functions, and evolutionary histories of linear biological macromolecules (DNA, RNA, and proteins), and for finding homologs in sequence databases. We address several ontological issues related to RNA sequence alignments that are informed by structure.
Brown, James W, Birmingham, Amanda, Griffiths, Paul E, Jossinet, Fabrice, Kachouri-Lafond, Rym, Knight, Rob, Lang, B Franz, Leontis, Neocles, Steger, Gerhard, Stombaugh, Jesse, Westhof, Eric   +10 more
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source