Results 61 to 70 of about 80,509 (303)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Ontology Alignment with OLA. [PDF]

open access: yes, 2004
Using ontologies is the standard way to achieve interoperability of heterogeneous systems within the Semantic web. However, as the ontologies underlying two systems are not necessarily compatible, they may in turn need to be aligned. Similarity-based approaches to alignment seems to be both powerful and flexible enough to match the expressive power of ...
Euzenat, Jérôme   +3 more
openaire   +1 more source

Results from experiments in ontology learning including evaluation and recommendation [PDF]

open access: yes, 2007
This document describes the Ontology Learning experiments we performed in order to recommend a set of ontology learning techniques to enhance the ontology engineering process in the fisheries domain in place at FAO. Experiments have been conceived in the
Caracciolo, Caterina   +4 more
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Linking Datasets Using Semantic Textual Similarity

open access: yesCybernetics and Information Technologies, 2018
Linked data has been widely recognized as an important paradigm for representing data and one of the most important aspects of supporting its use is discovery of links between datasets.
McCrae John P., Buitelaar Paul
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Bayesian Evaluation and Comparison of Ontology Alignment Systems

open access: yesIEEE Access, 2019
Ontology alignment systems are evaluated by various performance scores, which are usually computed by a ratio related directly to the frequency of the true positives.
Majid Mohammadi
doaj   +1 more source

Evaluating Ontology Modules Using an Entropy Inspired Metric

open access: yes, 2008
The focus of ontology modularization to date has largely been on the creation of techniques to carry out ontology modularization. This creates a problem in evaluating the results of the different techniques.
Paul Doran   +9 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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