Results 41 to 50 of about 283,563 (261)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Developing Contextual Ontology for Chronic Diseases: AI-Enhanced Extension and Prediction in an Asthma Case Study

Applied Sciences
The growing complexity and interdependence of healthcare data, especially for chronic diseases such as asthma, demand innovative approaches for effective knowledge representation.
Batoul Msheik, Mehdi Adda, Hamid Mcheick, Youmna Nasser, Mohamed Dbouk   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Comprehensive anatomic ontologies for lung development: A comparison of alveolar formation and maturation within mouse and human lung

Journal of Biomedical Semantics, 2019
Background Although the mouse is widely used to model human lung development, function, and disease, our understanding of the molecular mechanisms involved in alveolarization of the peripheral lung is incomplete.
Huaqin Pan, Gail H. Deutsch, Susan E. Wert, On behalf of the Ontology Subcommittee, NHLBI Molecular Atlas of Lung Development Program Consortium   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Capturing heart valve development with Gene Ontology

Frontiers in Genetics, 2023
Introduction: The normal development of all heart valves requires highly coordinated signaling pathways and downstream mediators. While genomic variants can be responsible for congenital valve disease, environmental factors can also play a role. Later in
Saadullah H. Ahmed, Alexander T. Deng, Rachael P. Huntley, Nancy H. Campbell, Ruth C. Lovering   +4 more
doaj   +1 more source

Development of Ontology for Information Literary

Procedia Computer Science, 2015
AbstractIt has been 20 years since the Internet, Internet crimes have been moving to the second stage in recent years. The awareness raising activities that are being conducted by various industry associations greatly contribute to reducing the troubles that are taking place now; these activities are to be favorably evaluated to a certain extent ...
Hiroko Kanoh, Kouji Kozaki, Motohiro Hasegawa, Takaaki Hishida   +3 more
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Ontological Framework for the Analysis of Outcome-Based Curriculum in Higher Education

IEEE Access
Outcome-Based Education (OBE) is a globally recognized approach for enhancing educational quality and aligning academic programs with industry needs.
Siti Aminah, Adila Alfa Krisnadhi, Achmad Nizar Hidayanto   +2 more
doaj   +1 more source

The African wildlife ontology tutorial ontologies

Journal of Biomedical Semantics, 2020
Background Most tutorial ontologies focus on illustrating one aspect of ontology development, notably language features and automated reasoners, but ignore ontology development factors, such as emergent modelling guidelines and ontological principles ...
C. Maria Keet
doaj   +1 more source