Results 101 to 110 of about 246,657 (302)

Investigating the use of background knowledge for assessing the relevance of statements to an ontology in ontology evolution [PDF]

, 2009
The tasks of learning and enriching ontologies with new concepts and relations have attracted a lot of attention in the research community, leading to a number of tools facilitating the process of building and updating ontologies.
d'Aquin, Mathieu, Motta, Enrico, Sabou, Marta, Zablith, Fouad   +3 more
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A Lightweight Ontology for Enterprise Architecture Mining of API Gateway Logs

IEEE Access
Enterprise Architecture (EA) is defined as a set of principles, methods, and models that support the design of organizational structures, expressing the different concerns of a company and its IT landscape, including processes, services, applications ...
Carlos Roberto Pinheiro, Sergio Luis Proenca Duarte Guerreiro, Henrique S. Mamede   +2 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Digital evolution: Novo Nordisk’s shift to ontology-based data management

Journal of Biomedical Semantics
The amount of biomedical data is growing, and managing it is increasingly challenging. While Findable, Accessible, Interoperable and Reusable (FAIR) data principles provide guidance, their adoption has proven difficult, especially in larger enterprises ...
Shawn Zheng Kai Tan, Shounak Baksi, Thomas Gade Bjerregaard, Preethi Elangovan, Thrishna Kuttikattu Gopalakrishnan, Darko Hric, Joffrey Joumaa, Beidi Li, Kashif Rabbani, Santhosh Kannan Venkatesan, Joshua Daniel Valdez, Saritha Vettikunnel Kuriakose   +11 more
doaj   +1 more source

Introduction [PDF]

, 1995
Husserl’s philosophy, by the usual account, evolved through three stages: 1. development of an anti-psychologistic, objective foundation of logic and mathematics, rooted in Brentanian descriptive psychology; 2.
Smith, Barry, Smith, David Woodruff
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A Prototype for Automating Ontology Learning and Ontology Evolution

Proceedings of the International Conference on Knowledge Engineering and Ontology Development, 2013
Ontology learning supports ontology engineers in the complex task of creating an ontology. Updating ontologies at regular intervals greatly increases the need for expensive expert contribution. This naturally leads to endeavors to automate the process wherever applicable. This paper presents a model for automated ontology learning and a prototype which
Wohlgenannt, Gerhard, Belk, Stefan, Schett, Matthias   +2 more
openaire   +4 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The Bone Dysplasia Ontology: integrating genotype and phenotype information in the skeletal dysplasia domain

BMC Bioinformatics, 2012
Background Skeletal dysplasias are a rare and heterogeneous group of genetic disorders affecting skeletal development. Patients with skeletal dysplasias suffer from many complex medical issues including degenerative joint disease and neurological ...
Groza Tudor, Hunter Jane, Zankl Andreas
doaj   +1 more source