Results 111 to 120 of about 246,657 (302)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Ontology evolution under semantic constraints

In Principles of Knowledge Representation and Reasoning: Proceedings of the Thirteenth International, 2012
The dynamic nature of ontology development has motivated the formal study of ontology evolution problems. This paper presents a logical framework that enables fine-grained investigation of evolution problems at a deductive level. In our framework, the optimal evolutions of an ontology O are those ontologies O′ that maximally preserve both the structure
Grau, B, Jimenez−Ruiz, E, Kharlamov, E, Zheleznyakov, D   +3 more
openaire   +1 more source

Guidelines for a Dynamic Ontology - Integrating Tools of Evolution and Versioning in Ontology

, 2011
Ontologies are built on systems that conceptually evolve over time. In addition, techniques and languages for building ontologies evolve too. This has led to numerous studies in the field of ontology versioning and ontology evolution. This paper presents
Cruz, Christophe, Nicolle, Christophe, Pittet, Perrine   +2 more
core   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Geographic Process Modeling Based on Geographic Ontology

Open Geosciences, 2018
Considerable attention has been paid to geographic process-based studies in geographic information science research. Finding appropriate methods to express geographic processes is challenging, and working to reveal the dynamic evolution and underlying ...
Cao Yuwei, Huang Yi, Chen Jing, Sheng YeHua   +3 more
doaj   +1 more source

The rise of the technobionts: toward a new ontology to understand current planetary crisis [PDF]

Inhere we expand the concept of Holobiont to incorporate niche construction theory in order to increase our understanding of the current planetary crisis. By this, we propose a new ontology, the Ecobiont, as the basic evolutionary unit of analysis.
Guijón, Gustavo Magallanes, López-Corona, O.   +1 more
core  

NFDI MatWerk Ontology (MWO): A BFO‐Compliant Ontology for Research Data Management in Materials Science and Engineering

Advanced Engineering Materials, EarlyView.
This article presents the NFDI‐MatWerk Ontology (MWO), a Basic Formal Ontology‐based framework for interoperable research data management in materials science and engineering (MSE). Covering consortium structures, research data management resources, services, and instruments, MWO enables semantic integration, Findable, Accessible, Interoperable, and ...
Hossein Beygi Nasrabadi, Ebrahim Norouzi, Kostiantyn Hubaiev, Jörg Waitelonis, Harald Sack   +4 more
wiley   +1 more source

Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows

Advanced Engineering Materials, EarlyView.
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba, Sang‐Hyeok Lee, Christina Gasper, Martina Freund, Sandra Korte‐Kerzel, Ulrich Kerzel   +5 more
wiley   +1 more source

A Cloud-Edge-End Collaborative Framework for Adaptive Process Planning by Welding Robots

Machines
The emergence of mass personalized production has increased the adaptability and intelligence requirements of welding robots. To address the challenges associated with mass personalized production, this paper proposes a novel knowledge-driven framework ...
Kangjie Shi, Weidong Shen
doaj   +1 more source