Results 41 to 50 of about 246,657 (302)
Matching biomedical ontologies through compact differential evolution algorithm
Systems Science & Control Engineering, 2019 Although biomedical ontologies have been widely used in the life science domain, the heterogeneous problem among biomedical ontologies hampers their inter-operability.
Xingsi Xue, Junfeng Chen
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Ontology Evolution with Evolva [PDF]
, 2009 Ontology evolution is a painstaking and time-consuming process, especially in information rich and dynamic domains. While ontology evolution refers both to the adaptation of ontologies (e.g., through additions or updates possibly discovered from external data sources) and the management of these changes, no existing tools offer both functionalities ...
Zablith, Fouad +3 more
openaire +1 more source
Composite ontology change operators and their customizable evolution strategies [PDF]
, 2012 Change operators are the building blocks of ontology evolution. Elementary, composite and complex change operators have been suggested. While lower-level change operators are useful in terms of finegranular representation of ontology changes ...
Abgaz, Yalemisew +2 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Ontology of Gender in Computer Games
Mise au Point, 2014 This article aims to illustrate how social ontology can replace traditional constructivist approaches to media analysis. The focus is on the relation between sexual identity and computer games, both categorized using social ontology tools. Computer games
Ivan Mosca
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A layered framework for pattern-based ontology evolution [PDF]
, 2011 The challenge of ontology-driven modelling of information components is well known in both academia and industry. In this paper, we present a novel approach to deal with customisation and abstraction of ontology-based model evolution.
Abgaz, Yalemisew +2 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Using background knowledge for ontology evolution [PDF]
, 2008 One of the current bottlenecks for automating ontology evolution is resolving the right links between newly arising information and the existing knowledge in the ontology. Most of existing approaches mainly rely on the user when it comes to capturing and
d'Aquin, Mathieu +3 more
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source