Results 61 to 70 of about 246,657 (302)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Complexity, BioComplexity, the Connectionist Conjecture and Ontology of Complexity\ud [PDF]
, 2009 This paper develops and integrates major ideas and concepts on complexity and biocomplexity - the connectionist conjecture, universal ontology of complexity, irreducible complexity of totality & inherent randomness, perpetual evolution of information,
Mukherjee, Mr. Debaprasad
core
On the Common Structure of Bohmian Mechanics and the Ghirardi-Rimini-Weber Theory [PDF]
, 2006 Bohmian mechanics and the Ghirardi-Rimini-Weber theory provide opposite resolutions of the quantum measurement problem: the former postulates additional variables (the particle positions) besides the wave function, whereas the latter implements ...
Allori, Valia +3 more
core +9 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
OnEX: Exploring changes in life science ontologies
BMC Bioinformatics, 2009 Background Numerous ontologies have recently been developed in life sciences to support a consistent annotation of biological objects, such as genes or proteins.
Gross Anika +3 more
doaj +1 more source
How do Ontology Mappings Change in the Life Sciences? [PDF]
, 2012 Mappings between related ontologies are increasingly used to support data integration and analysis tasks. Changes in the ontologies also require the adaptation of ontology mappings.
Gross, Anika +3 more
core
Empirical analysis of impacts of instance-driven changes in ontologies [PDF]
, 2010 Changes in the characterization of instances in digital contents are one of the rationales to change or evolve ontologies which support the domain. These changes can impacts on one or more of interrelated ontologies.
Abgaz, Yalemisew, Pahl, Claus
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Self-adaptive GA, quantitative semantic similarity measures and ontology-based text clustering [PDF]
, 2008 As the common clustering algorithms use vector space model (VSM) to represent document, the conceptual relationships between related terms which do not co-occur literally are ignored.
Li, Chenghua +3 more
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source