Results 121 to 130 of about 103,296 (308)

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

open access: yesAdvanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang   +7 more
wiley   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang   +17 more
wiley   +1 more source

USE OF ONTOLOGIES FOR KNOWLEDGE BASES CREATION TUTORING COMPUTER SYSTEMS

open access: yesÌнформаційні технології в освіті, 2014
This paper deals with the use of ontology for the use and development of intelligent tutoring systems. We consider the shortcomings of educational software and distance learning systems and the advantages of using ontology’s in their design.
Cheremisina Lyubov
doaj  

Ontology Mapping: A Way Out of the Medical Tower of Babel? [PDF]

open access: yes, 2005
Integration of different information sources has been a problem that has been challenging (or perhaps better: plaguing) Computer Science throughout the decades. As soon as we had two computers, we wanted to exchange information between them, and as soon as we had two databases, we wanted to link them together.
openaire   +2 more sources

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

open access: yesAdvanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen   +6 more
wiley   +1 more source

Changing Ontology Breaks the Queries

open access: yes, 2006
Updating an ontology that is in use may result in inconsistencies between the ontology and the knowledge base, dependent ontologies and applications/services.
Liang, Yaozhong   +2 more
core  

Towards more Challenging Problems for Ontology Matching Tools

open access: yes, 2011
We motivate the need for challenging problems in the evaluation of ontology matching tools. To address this need, we propose mapping sets between well-known biomedical ontologies that are based on the UMLS Metathesaurus. These mappings could be used as a
Grau, B.Cuenca   +5 more
core   +1 more source

3D‐Printed Piezoionic/Bioelectronic Hydrogel for Electro‐Metabolic Regulation of Osteogenic Differentiation

open access: yesAdvanced Healthcare Materials, EarlyView.
A 3D‐printed piezoionic GPMx hydrogel enables stable electromechanical signal generation under mechanical loading, exhibiting long‐term durability and low fatigue. As a bioactive patch, it restores endogenous bioelectricity to stimulate osteogenesis via Ca2+ influx and mitochondrial activation, while simultaneously enabling label‐free alkaline ...
Sayan Deb Dutta   +3 more
wiley   +1 more source

A Versatile Microfluidic Extrusion‐Based Hydrogel Platform for Self‐Organization and Long‐Term Maintenance of Engineered 3D Lymphatic Endothelium

open access: yesAdvanced Healthcare Materials, EarlyView.
Microfluidic coaxial extrusion generates size‐controlled 3D lymphatic tubes from primary human dermal lymphatic endothelial cells in a defined four‐component matrix. These engineered vessels self‐organize into stable lymphatic endothelium, maintain selective macromolecular permeability for 30 days, and enable direct comparison with blood endothelial ...
Elsa Mazari‐Arrighi   +8 more
wiley   +1 more source

An experiment with ontology mapping using concept similarity

open access: yes, 2004
This paper describes a system for automatically mapping between concepts in different ontologies. The motivation for the research stems from the Diogene project, in which the project's own ontology covering the ICT domain is mapped to external ontologies,
Crestani, F.   +5 more
core   +1 more source

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