Results 91 to 100 of about 1,139,414 (359)

Towards information profiling: data lake content metadata management [PDF]

open access: yes, 2016
There is currently a burst of Big Data (BD) processed and stored in huge raw data repositories, commonly called Data Lakes (DL). These BD require new techniques of data integration and schema alignment in order to make the data usable by its consumers ...
Abelló Gamazo, Alberto   +3 more
core   +1 more source

Single‐Cell RNA Seq in Sydenham Chorea Shows B Cell HLA‐DR/DQ Upregulation and Plasma Cell Proteasomal Activation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han   +9 more
wiley   +1 more source

Semantic web service architecture for simulation model reuse [PDF]

open access: yes, 2007
COTS simulation packages (CSPs) have proved popular in an industrial setting with a number of software vendors. In contrast, options for re-using existing models seem more limited.
Bell, D   +4 more
core   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou   +12 more
wiley   +1 more source

How do Ontology Mappings Change in the Life Sciences? [PDF]

open access: yes, 2012
Mappings between related ontologies are increasingly used to support data integration and analysis tasks. Changes in the ontologies also require the adaptation of ontology mappings.
Gross, Anika   +3 more
core  

Flexible coordination techniques for dynamic cloud service collaboration [PDF]

open access: yes, 2012
The provision of individual, but also composed services is central in cloud service provisioning. We describe a framework for the coordination of cloud services, based on a tuple‐space architecture which uses an ontology to describe the services. Current
Creaner, Gary, Pahl, Claus
core   +1 more source

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

open access: yesArthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla   +13 more
wiley   +1 more source

Discovering gene annotations in biomedical text databases

open access: yesBMC Bioinformatics, 2008
Background Genes and gene products are frequently annotated with Gene Ontology concepts based on the evidence provided in genomics articles. Manually locating and curating information about a genomic entity from the biomedical literature requires vast ...
Ozsoyoglu Gultekin, Cakmak Ali
doaj   +1 more source

An information retrieval approach to ontology mapping [PDF]

open access: yes, 2006
In this paper, we present a heuristic mapping method and a prototype mapping system that support the process of semi-automatic ontology mapping for the purpose of improving semantic interoperability in heterogeneous systems.
Gulla, J.A., Su, X.
core   +3 more sources

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

open access: yesAdvanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo   +8 more
wiley   +1 more source

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