Results 71 to 80 of about 134,903 (295)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
MaF: An Ontology Matching Framework
, 2012 In this work, we present our experience when developing the Matching Framework (MaF), a framework for matching ontologies that allows users to configure their own ontology matching algorithms and it allows developers to perform research on new complex algorithms.
Martinez-Gil, Jorge +2 more
openaire +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
An Iterative Automatic Final Alignment Method in the Ontology Matching System
Journal of Information and Organizational Sciences, 2018 Ontology matching plays an important role in the integration of heterogeneous data sources that are described by ontologies. In order to determine correspondences between ontologies, a set of matchers can be used.
Marko Gulić +2 more
doaj +1 more source
A Large Scale Dataset for the Evaluation of Ontology Matching Systems [PDF]
, 2008 Recently, the number of ontology matching techniques and systems has increased significantly. This makes the issue of their evaluation and comparison more severe.
Avesani, Paolo +3 more
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Community-Driven Ontology Matching [PDF]
, 2006 We extend the notion of ontology matching to community-driven ontology matching. Primarily, the idea is to enable Web communities to establish and reuse ontology mappings in order to achieve, within those communities, an adequate and timely domain representation, facilitated knowledge exchange, etc.
Anna V. Zhdanova, Pavel Shvaiko
openaire +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Block Matching for Ontologies [PDF]
, 2006 Ontology matching is a crucial task to enable interoperation between Web applications using different but related ontologies. Today, most of the ontology matching techniques are targeted to find 1:1 mappings. However, block mappings are in fact more pervasive.
Wei Hu, Yuzhong Qu
openaire +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source