Results 51 to 60 of about 821,533 (281)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Matching biomedical ontologies through compact differential evolution algorithm
Systems Science & Control Engineering, 2019 Although biomedical ontologies have been widely used in the life science domain, the heterogeneous problem among biomedical ontologies hampers their inter-operability.
Xingsi Xue, Junfeng Chen
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Tackling the challenges of matching biomedical ontologies
Journal of Biomedical Semantics, 2018 Background Biomedical ontologies pose several challenges to ontology matching due both to the complexity of the biomedical domain and to the characteristics of the ontologies themselves.
Daniel Faria +5 more
doaj +1 more source
Ontology Matching with Knowledge Rules [PDF]
, 2016 Ontology matching is the process of automatically determining the semantic equivalences between the concepts of two ontologies. Most ontology matching algorithms are based on two types of strategies: terminology-based strategies, which align concepts based on their names or descriptions, and structure-based strategies, which exploit concept hierarchies
Shangpu Jiang +3 more
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Optimizing Sensor Ontology Alignment through Compact co-Firefly Algorithm
Sensors, 2020 Semantic Sensor Web (SSW) links the semantic web technique with the sensor network, which utilizes sensor ontology to describe sensor information. Annotating sensor data with different sensor ontologies can be of help to implement different sensor ...
Xingsi Xue, Junfeng Chen
doaj +1 more source
Improving Ontology Matching Using Application Requirements for Segmenting Ontologies [PDF]
Journal of Universal Computer Science, 2019 Ontology matching is concerned with finding relations between elements of different ontologies. In large-scale settings, some significant challenges arise, such as how to achieve a reduction in the time it takes to perform matching and how to improve the
Diego Pessoa +2 more
doaj +3 more sources
Matching Biomedical Ontologies via a Hybrid Graph Attention Network
Frontiers in Genetics, 2022 Biomedical ontologies have been used extensively to formally define and organize biomedical terminologies, and these ontologies are typically manually created by biomedical experts. With more biomedical ontologies being built independently, matching them
Peng Wang, Peng Wang, Yunyan Hu
doaj +1 more source
Dealing with uncertain entities in ontology alignment using rough sets [PDF]
, 2012 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2012 IEEE. Personal use of this material is permitted.
Li, M +3 more
core +1 more source