Results 61 to 70 of about 1,176,214 (330)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Ontology Matching with Knowledge Rules [PDF]

, 2016
Ontology matching is the process of automatically determining the semantic equivalences between the concepts of two ontologies. Most ontology matching algorithms are based on two types of strategies: terminology-based strategies, which align concepts based on their names or descriptions, and structure-based strategies, which exploit concept hierarchies
Shangpu Jiang, Daniel Lowd, Sabin Kafle, Dejing Dou   +3 more
openaire   +3 more sources

Tackling the challenges of matching biomedical ontologies

Journal of Biomedical Semantics, 2018
Background Biomedical ontologies pose several challenges to ontology matching due both to the complexity of the biomedical domain and to the characteristics of the ontologies themselves.
Daniel Faria, Catia Pesquita, Isabela Mott, Catarina Martins, Francisco M. Couto, Isabel F. Cruz   +5 more
doaj   +1 more source

Results of the Ontology Alignment Evaluation Initiative 2021

, 2022
62108The Ontology Alignment Evaluation Initiative (OAEI) aims at comparing ontology matching systems on precisely defined test cases. These test cases can be based on ontologies of different levels of complexity and use different evaluation modalities (e.
Jimenez-Ruiz, E., Michel, F., Roussey, C., Zamaza, O., Karam, N., Paulheim, H., Li, Y., Faria, D., Hertling, S., Fundulaki, I., Pesquita, C., Amini, R., Harrow, I., Splendiani, A., Vatascinova, J., Amardeilh, F., Yaman, B., Nasr, E., Pour, M.A.N., Portisch, J., Saveta, T., Fallatah, O., Laadhar, A., Huschka, M., Zhou, L., Shvaiko, P., Trojahn, C., Ibanescu, L., Algergawy, A., Lambrix, P., Li, H., Hitzler, P.   +31 more
core  

Argumentation over Ontology Correspondences in MAS [PDF]

, 2007
In order to support semantic interoperation in open environments, where agents can dynamically join or leave and no prior assumption can be made on the ontologies to align, the different agents involved need to agree on the semantics of the terms used ...
Trevor Bench-Capon, Terry Payne, Payne, Terry R., Euzenat, Jerome, Payne, Terry, Bench-Capon, Trevor, Ian Blacoe, Jerôme Euzenat, Loredana Laera, Tamma, Valentina, Valentina Tamma, Laera, Loredana, Blacoe, Ian   +12 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Matching biomedical ontologies through compact differential evolution algorithm

Systems Science & Control Engineering, 2019
Although biomedical ontologies have been widely used in the life science domain, the heterogeneous problem among biomedical ontologies hampers their inter-operability.
Xingsi Xue, Junfeng Chen
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A Comparative Study of Ontology Matching Systems via Inferential Statistics

IEEE Transactions on Knowledge and Data Engineering, 2019
Ontology matching systems are typically compared by comparing their average performances over multiple datasets. However, this paper examines the alignment systems using statistical inference since averaging is statistically unsafe and inappropriate. The
M. Mohammadi, W. Hofman, Yao-Hua Tan
semanticscholar   +1 more source