Results 41 to 50 of about 38,910 (305)
CroMatcher 2.0: A Comprehensive Analysis of the Improved Ontology Matching System
IEEE AccessOne of the main challenges in ontology matching is to match ontologies with high accuracy. Therefore, ontology matching systems typically use multiple basic matchers, each targeting a specific ontology component for the matching process.
Marko Gulic +2 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Optimizing Sensor Ontology Alignment through Compact co-Firefly Algorithm
Sensors, 2020 Semantic Sensor Web (SSW) links the semantic web technique with the sensor network, which utilizes sensor ontology to describe sensor information. Annotating sensor data with different sensor ontologies can be of help to implement different sensor ...
Xingsi Xue, Junfeng Chen
doaj +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Matching biomedical ontologies through compact differential evolution algorithm
Systems Science & Control Engineering, 2019 Although biomedical ontologies have been widely used in the life science domain, the heterogeneous problem among biomedical ontologies hampers their inter-operability.
Xingsi Xue, Junfeng Chen
doaj +1 more source
Tackling the challenges of matching biomedical ontologies
Journal of Biomedical Semantics, 2018 Background Biomedical ontologies pose several challenges to ontology matching due both to the complexity of the biomedical domain and to the characteristics of the ontologies themselves.
Daniel Faria +5 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Journal of King Saud University: Computer and Information Sciences, 2014 Hierarchical ontologies play a key role in organizing documents in a repository. While matching the ontologies, the relationships among the concepts are considered to be a major aspect.
Sharifullah Khan, Muhammad Safyan
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source