Results 61 to 70 of about 269,488 (343)
Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance MTOR (mechanistic target of rapamycin), an integrator of pathways important for cellular metabolism, proliferation, and differentiation, is expressed at all stages of oocyte development.
Jing Guo +14 more
semanticscholar +1 more source
Integration of Bioengineered Tools in Assisted Reproductive Technologies
Advanced Healthcare Materials, EarlyView.A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak +3 more
wiley +1 more source
Animal, 2023 The oocyte is the basis of life, supporting development from a fertilized cell to an independent multicellular organism. The oocyte’s competence to drive the first cell cycles postfertilization are critical to embryonic survival and subsequent successful
Camila Bortoliero Costa +2 more
doaj
Actin cytoskeleton dynamics in mammalian oocyte meiosis†
Biology of Reproduction, 2018 During mitosis, cells undergo symmetrical cell division, while oocyte meiotic maturation undergoes two consecutive, asymmetric divisions that generate a totipotent haploid oocyte and two small polar bodies not involved in DNA replication.
Xing Duan, Shao‐Chen Sun
semanticscholar +1 more source
Advanced Science, EarlyView.DECENT is a deep learning method that enhances noninvasive preimplantation genetic testing by accurately reconstructing embryonic copy number variations (CNVs) from cell‐free DNA in spent embryo culture media. By mitigating maternal contamination, DECENT improves diagnostic accuracy, even with high contamination levels, offering a reliable, noninvasive
Zhenyi Zhang +3 more
wiley +1 more source
Ovarian aging: energy metabolism of oocytes
Journal of Ovarian ResearchIn women who are getting older, the quantity and quality of their follicles or oocytes and decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, and lower quality oocytes.
Shenglan Bao, Tailang Yin, Su Liu
doaj +1 more source
Mutations in TUBB8 and Human Oocyte Meiotic Arrest.
New England Journal of Medicine, 2016 Background Human reproduction depends on the fusion of a mature oocyte with a sperm cell to form a fertilized egg. The genetic events that lead to the arrest of human oocyte maturation are unknown.
Ruizhi Feng +32 more
semanticscholar +1 more source
Advanced Science, EarlyView.ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma +18 more
wiley +1 more source
Integrated Environmental Assessment and Management, EarlyView., 2023 Abstract In the Lake Koocanusa‐Kootenai River system (Montana, USA and British Columbia, Canada), selenium (Se) contamination has become an international concern and is suspected to contribute to the observed burbot (Lota lota) population collapse. Due to our limited ability to sample burbot in Lake Koocanusa for monitoring studies, we used a reference
Stephanie D. Graves +6 more
wiley +1 more source
Reproductive Biology and Endocrinology, 2009 Background Ovarian stimulation for assisted reproductive technology (ART) overcomes the physiologic process to develop a single dominant follicle. However, following stimulation, egg recovery rates are not 100%.
Rinaudo Paolo F +7 more
doaj +1 more source