Results 211 to 220 of about 6,215 (307)

Ectogenesis and gender inequality: Two pathways converge

open access: yesBioethics, EarlyView.
Abstract Debate on whether ectogenesis is a morally desirable solution to gender inequality often starts by analyzing whether gender inequality has been caused by (i) reproductive differences between the sexes or (ii) social structures. I term these two sides the biological model and the social model.
Jolie Zhou
wiley   +1 more source

Simulated gestation: The social and ethical implications of in vivo fertilisation technology

open access: yesBioethics, EarlyView.
Abstract INVOcell is an in vivo fertilisation device marketed as an alternative to in vitro fertilisation treatment. In this paper, we explore the ethical implications that arise when this device is framed as a type or process of ‘gestation’. We anticipate several effects that may be of ethical interest: marketing in vivo fertilisation as being ...
Ji‐Young Lee   +2 more
wiley   +1 more source

Pharmacological evaluation of non‐nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage‐associated molecular patterns, such as ATP release, recognised by P2X7 receptors.
Inés Valencia   +15 more
wiley   +1 more source

Beyond synapses: cytoplasmic connections in brain function and evolution

open access: yesBiological Reviews, EarlyView.
ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh   +4 more
wiley   +1 more source

Two Novel Protein‐Truncating Variants in NLRP2 and Their Functional Impacts on the Subcortical Maternal Complex

open access: yesClinical Genetics, EarlyView.
Two deleterious protein‐truncating NLRP2 variants were identified in a patient with female infertility, four early miscarriages, and one failed attempt of intracytoplasmic sperm injection. The variants mediate mRNA decay and alter NLRP2 structure and interactions with other members of the SCMC.
Zeynep Yalcin   +8 more
wiley   +1 more source

Ciliary IFT‐B Transportation Plays an Important Role in Human Endometrial Receptivity Establishment and is Disrupted in Recurrent Implantation Failure Patients

open access: yesCell Proliferation, EarlyView.
Our results suggested that mitochondria‐accelerated motile cilia intraflagellar transport may be involved in endometrial microenvironment establishment. ABSTRACT The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent ...
Haoxuan Yang   +17 more
wiley   +1 more source

What is the clinical impact of the endometrial receptivity array in PGT-A and oocyte donation cycles? [PDF]

open access: yesJ Assist Reprod Genet, 2019
Neves AR   +6 more
europepmc   +1 more source

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